{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:50:47Z","timestamp":1793515847607,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473138"],"award-info":[{"award-number":["52473138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173287"],"award-info":[{"award-number":["52173287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52433015"],"award-info":[{"award-number":["52433015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multidrug\u2010resistant (MDR) bacterial infections pose a significant threat to human health, particularly when introduced by surgical contamination, resulting in early\u2010stage implant\u2010related biofilm infections and potential implant failure. Inspired by the structure and function of lysozyme fibers, a biomimetic supramolecular hydrogel is developed that mimics the lysozyme fiber architecture and encapsulates D\u2010tyrosine (D\u2010Tyr), integrating bactericidal and anti\u2010biofilm functions within a self\u2010assembled positively charged nanofibrous network. The peptide backbone with quaternary ammonium salt\u2010modified fibers disrupts bacterial cell membranes through direct contact, thereby damaging structural integrity, causing cytoplasmic leakage and killing bacteria; meanwhile, D\u2010Tyr's effective sustained release inhibits initial bacterial contamination and prevents subsequent biofilm formation. In vivo, experiments demonstrated that the hydrogel significantly accelerated the healing of Methicillin\u2010resistant Staphylococcus aureus (MRSA)\u2010infected skin abscesses and prevented implant\u2010related biofilm infections during the preliminary stages of implantation. By exploiting synergistic bactericidal and anti\u2010biofilm effects, this lysozyme fiber\u2010inspired hydrogel offers a promising strategy to combat MDR bacterial infections and prevent biofilm\u2010related implant complications.<\/jats:p>","DOI":"10.1002\/adhm.202500687","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:30:52Z","timestamp":1748914252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lysozyme Fiber\u2010Inspired Versatile Supramolecular Hydrogel Against Drug\u2010Resistant Pathogens and Biofilm Formation"],"prefix":"10.1002","volume":"14","author":[{"given":"Xirui","family":"Long","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"He","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Zhen","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxi","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehua","family":"Li","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0695-1619","authenticated-orcid":false,"given":"Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Med\u2010X Center of Materials Sichuan University Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14689"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.10.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1212788"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1801-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182778590"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11061614"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00986E"},{"key":"e_1_2_9_5_3","doi-asserted-by":"publisher","DOI":"10.1159\/000491497"},{"key":"e_1_2_9_5_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00905-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0019-y"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199401000-00016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09506608.2023.2193784"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565020-00003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/713610448"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196305"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045104"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01599"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c00870"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00405-6"},{"key":"e_1_2_9_11_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02872-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c01597"},{"key":"e_1_2_9_13_1","first-page":"724","volume":"18","author":"Tang Y.","year":"2025","journal-title":"J. Adv. Res."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TA07236E"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/am4022279"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b13552"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf9507147"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c00924"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.162605"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2016.01.037"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(04)83013-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2016.03.081"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c07225"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304536"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2024.141386"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101793"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.17.5549-5559.1992"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178123"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10983"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188628"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00254-z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.09.015"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb0025"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbw001"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.53.5.647"},{"key":"e_1_2_9_30_3","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.1052"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102228"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111116"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202500687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:47:24Z","timestamp":1759744044000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202500687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":49,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/adhm.202500687"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202500687","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]},"assertion":[{"value":"2025-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2500687"}}