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In this study, a pH\u2010responsive dual\u2010mode MRI nanoprobe, Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@MnS\u2010transferrin (FMT), is prepared with the objective of augmenting tumor visualization and chemodynamic therapy (CDT). FMT achieved precise tumor targeting by binding to transferrin receptors on cancer cells via the transferrin molecules on their surface. FMT underwent pH\u2010responsive decomposition in the acidic tumor microenvironment, releasing Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> and Mn<jats:sup>2+<\/jats:sup>. This decomposition increased the spatial separation between Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> and Mn<jats:sup>2+<\/jats:sup>, attenuating the mutual magnetic shielding effect and activating dual\u2010mode MRI function. Moreover, FMT released Mn<jats:sup>2+<\/jats:sup> and hydrogen sulfide (H<jats:sub>2<\/jats:sub>S). Mn<jats:sup>2+<\/jats:sup> triggered a Fenton\u2010like reaction, generating reactive oxygen species that induced cytotoxicity through CDT. Concurrently, H<jats:sub>2<\/jats:sub>S inhibited catalase activity, providing additional substrates for the Fenton\u2010like reaction, thereby amplifying CDT in a cascading manner. This synergistic mechanism amplified the cytotoxicity of CDT, enhancing the efficacy of tumor treatment and metastasis inhibition. Therefore, FMT demonstrated significant promise for enhancing both the precision of tumor imaging and the efficacy of treatment.<\/jats:p>","DOI":"10.1002\/adhm.202500690","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:14:08Z","timestamp":1753172048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transferrin\u2010Targeted Nanoarchitectonics with Efficient Metastasis Inhibition Enabling Tumor T<sub>1<\/sub>\u2010T<sub>2<\/sub> Dual\u2010Mode Magnetic Resonance Contrast Enhancement"],"prefix":"10.1002","volume":"14","author":[{"given":"Yinuo","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Ultrasound Central Hospital Affiliated to Shandong First Medical University  Jinan 250013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Tian","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University &amp; 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