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Herein, a multifunctional selenium\u2010albumin nanoaccelerator hydrogel (H\u2010Se NPs\u2010Gel) is constructed based on the self\u2010assembly of human serum albumin (HSA) with selenium nanoparticles (Se NPs) using carbomer as the carrier, it has remarkable antibacterial, anti\u2010inflammatory, antioxidant and inhibits scarring properties than Se NPs for wound healing. Compared with Se NPs, H\u2010Se NPs exhibit smaller particle sizes, exceptional stability, better antibacterial activity against common bacteria and MRSA, and superior antioxidant and anti\u2010inflammatory capabilities in vitro without remarkable toxicity on skin cells. Importantly, it exhibits superior efficacy to Se NPs\u2010Gel in accelerating the healing of full\u2010thickness skin defects and diabetic wounds in mice. Interestingly, in a hypertrophic scar (HTS) model, H\u2010Se NPs\u2010Gel is more effective than Se NPs\u2010Gel in inhibiting collagen formation to suppress scarring, which is mediated by the inhibition of CD36. The antagonistic effect of H\u2010Se NPs on CD36 is also proved with the CD36 overexpression model. Furthermore, H\u2010Se NPs\u2010Gel demonstrates excellent safety in mice without systemic toxicity. H\u2010Se NPs\u2010Gel is an effective and safe therapy strategy for promoting wound healing and reducing scar formation in clinic.<\/jats:p>","DOI":"10.1002\/adhm.202500699","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:15:02Z","timestamp":1747386902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Selenium\u2010Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti\u2010Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36"],"prefix":"10.1002","volume":"14","author":[{"given":"Lulu","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Key Laboratory for Pharmaceutical Metabolism Research College of Pharmacy Chongqing Medical University  Chongqing 400016 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