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Therefore, functional hydrogel dressings with the ability to regulate the microenvironment of diabetic wounds are a promising strategy for the treatment of diabetic wounds. In this study, a pH\/glucose dual\u2010responsive hydrogel based on phenylboric acid\u2010modified carboxymethyl chitosan (CMCSPBA), aldehyde\u2010terminated polyethylene glycol (PEGCHO), and polyvinyl alcohol (PVA) has been developed for diabetic wound treatment via Schiff base and phenylboric ester interactions. Glucose oxidase (GOX), catalase (CAT), and deferoxamine mesylate (DFO) are incorporated into the hydrogel to endow it with multi\u2010functionality. In the hyperglycemic environment of diabetic wounds, a benign feedback loop is formed through the synergistic action of each component of the hydrogel, which enables the reshaping of the microenvironment of diabetic wounds by adjusting the pH and glucose, alleviating oxidative stress and hypoxia, regulating the inflammatory response, inhibiting bacterial infection, and promoting angiogenesis, thus accelerating diabetic wound healing in streptozotocin (STZ)\u2010induced diabetic mice.<\/jats:p>","DOI":"10.1002\/adhm.202500810","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:13:06Z","timestamp":1744783986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["pH and Glucose Dual\u2010Responsive Hydrogels Promoted Diabetic Wound Healing by Remodeling the Wound 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