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Clinically, it has no effective medical therapy but can be managed with artificial heart valve replacement, particularly using bioprosthetic heart valves (BHV), entailing high biocompatibility. Current BHV mainly derives from glutaraldehyde (GA) cross\u2010linked pericardium, however, residual aldehyde groups may inevitably remain during cross\u2010link, potentially binding with calcium and inducing in situ calcification after implantation, thus leading to valve re\u2010failure and posing a significant clinical challenge. Inspired by the high reducibility and clinical potential of sodium thiosulfate (STS), herein, STS as a novel modification post GA cross\u2010linking to eliminate residual aldehyde in pericardium is presented. Notably, in vitro and in vivo studies demonstrated high ability against calcification in STS\u2010modified porcine pericardium (SPP) with over 75% decrease of calcific density compared to GA alone cross\u2010linked pericardium (GPP). More importantly, SPP can reduce macrophages and T cell inflation, as well as their associated proinflammation cytokines, building an immune\u2010privileged microenvironment with a suppressed inflammation response. More generally, given the great potential of STS in treating vascular calcification clinically, these achievements further offer a new generation of BHV materials with boosted anti\u2010calcification.<\/jats:p>","DOI":"10.1002\/adhm.202500856","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:21:12Z","timestamp":1748244072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Novel Aldehyde Scavenging Modification Boosted Pericardium Valve Materials against Calcification"],"prefix":"10.1002","volume":"14","author":[{"given":"Fei","family":"Kong","sequence":"first","affiliation":[{"name":"Institute for Smart Biomedical Materials School of Materials Science &amp; Engineering Zhejiang Sci\u2010Tech University  Hangzhou Zhejiang 310018 China"},{"name":"Zhejiang\u2010Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci\u2010Tech University  Hangzhou Zhejiang 310018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Smart Biomedical Materials School of Materials Science &amp; 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