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Recent advances at the intersection of reproductive medicine and bioengineering offer promising avenues to enhance assisted reproductive technologies (ART). This review synthesizes emerging microengineered and stem cell\u2010based platforms designed to improve key ART stages from gamete handling and fertilization to embryo culture and implantation. State\u2010of\u2010the\u2010art microfluidic systems that refine sperm selection by leveraging directional behavioral responses, enhancing motility, and preserving DNA integrity is discussed. Moreover, devices for oocyte denudation and cryopreservation have been developed to mitigate cellular stress associated with conventional processing techniques. While microengineered platforms demonstrate promise in sperm sorting and reducing stress on gametes, their broader application in ART, particularly for oocyte handling and embryo culture, requires further development. The review further addresses stem cell\u2010based embryo models and bioengineered endometrial platforms, which aim to recapitulate the dynamic in vivo microenvironments needed for successful fertilization, embryo development, and implantation. Despite encouraging preliminary results, challenges such as scalability, reproducibility, clinical validation, and ethical considerations remain. By identifying these gaps and proposing future directions, this review considers integrating microengineering and bioengineering approaches to streamline ART procedures, ultimately enabling more personalized and effective reproductive therapies.<\/jats:p>","DOI":"10.1002\/adhm.202500918","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T04:55:25Z","timestamp":1750049725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Integration of Bioengineered Tools in Assisted Reproductive Technologies"],"prefix":"10.1002","volume":"14","author":[{"given":"Asl\u0131","family":"Ak","sequence":"first","affiliation":[{"name":"Department of Cell Biology\u2010Inspired Tissue Engineering (cBITE) MERLN Institue for Technology\u2010Inspired Regenerative Medicine Maastricht University  Maastricht 6229 ET The Netherlands"},{"name":"Department of Obstetrics and Gynaecology GROW Research Institute for Oncology and Reproduction Maastricht University  Maastricht 6229 ET The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Coonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology GROW Research Institute for Oncology and Reproduction Maastricht University  Maastricht 6229 ET The Netherlands"},{"name":"Department of Clinical Genetics Maastricht University Medical Centre (MUMC+)  Maastricht 6229 HX The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"van Golde","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology GROW Research Institute for Oncology and Reproduction Maastricht University  Maastricht 6229 ET The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-5609","authenticated-orcid":false,"given":"Erik","family":"Vrij","sequence":"additional","affiliation":[{"name":"Department of Cell Biology\u2010Inspired Tissue Engineering (cBITE) MERLN Institue for Technology\u2010Inspired Regenerative Medicine Maastricht University  Maastricht 6229 ET The Netherlands"},{"name":"Department of Obstetrics and Gynaecology GROW Research Institute for Oncology and Reproduction Maastricht University  Maastricht 6229 ET The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv016"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.4788"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0836-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32667-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.02.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.09.006"},{"key":"e_1_2_7_9_1","first-page":"131","volume":"12","author":"Hasanpoor\u2010Azghdy S. 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