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In this study, novel Sr\n                    <jats:sup>2+<\/jats:sup>\n                    \/Zn\n                    <jats:sup>2+<\/jats:sup>\n                    co\u2010doped mesoporous silica nanoparticles (MSNs) are fabricated using a designated substitution and etching method. The obtained SrZn\u2010MSNs possess unique hollow mesoporous structures, round spherical morphology, high specific surface areas, and suitable pore sizes. On this basis, gelatin methacrylate is combined with SrZn\u2010MSNs to construct injectable photo\u2010crosslinked hydrogels characterized by desired 3D interconnected porous structure, rough micro\u2010surface topography, sustained Sr\/Zn ions releasing, improved biomineralization and mechanical properties. These satisfactory properties allow SrZn\u2010MSNs to fully exert their bioactivity in composite hydrogels, efficiently ameliorating osteoporotic osseointegration around Ti alloys without drug loading. Direct cell culture on composite hydrogels further confirms the superior biological multifunctionality of SrZn\u2010MSNs to positively manipulate the coupling of immunoregulation\u2010osteogenesis\u2010angiogenesis, depending on the synergetic actions of bioactive Sr\n                    <jats:sup>2+<\/jats:sup>\n                    \/Zn\n                    <jats:sup>2+<\/jats:sup>\n                    . Furthermore, the underlying molecular mechanism responsible for enhanced osteogenesis of SrZn\u2010MSNs is clarified to be the upregulated PI3K\u2010AKT pathway, mainly mediated by activated integrin (Itg\u03b28, Itg\u03b14) and toll\u2010like receptor (Tlr2) signaling. These findings throw new insights into the fabrication of novel SrZn\u2010MSNs and highlight its superior biological multifunctionality and osteogenic mechanism, thus may providing a new practical strategy for bone healing.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500921","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:08:54Z","timestamp":1750050534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multifunctional Sr\n                    <sup>2+<\/sup>\n                    \/Zn\n                    <sup>2+<\/sup>\n                    Co\u2010Doped Mesoporous Silica Nanoparticles in Injectable Hydrogel for Ameliorating Osteoporotic Osseointegration"],"prefix":"10.1002","volume":"14","author":[{"given":"Wei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Orthopedics Wuxi Ninth People's Hospital Affiliated to Soochow University  Wuxi 214000 P. 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