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To date, the treatment of ischemic stroke is limited, and its consequent ischemia\u2010reperfusion injury is an important reason for this result. Excessive reactive oxygen species (ROS) and inflammatory storm followed by ischemia\u2010reperfusion alter the microenvironment of cerebral ischemic penumbra, leading to the devastating damage to the brain. Herein, we\u00a0design a black phosphorus nanosheets (BPNSs) loaded with magnesium ions (Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ) and polydopamine (PBP@Mg) to tackle the above problems. BPNSs of PBP@Mg effectively scavenge excessive ROS in neurocytes. Mg\n                    <jats:sup>2+<\/jats:sup>\n                    plays an anti\u2010inflammatory role in ischemic penumbra. Furthermore, polydopamine improves the stability of BPNSs. PBP@Mg is subsequently injected into the lateral ventricle of a rat model of ischemic stroke, resulting in an improvement of the ischemic microenvironment and a reduction in ischemic volume. BPNSs of PBP@Mg counteract against the excessive generation of ROS and the neuronal apoptosis in ischemic penumbra. Meanwhile, PBP@Mg dramatically suppresses inflammation by promoting the transformation of microglia from M1 to M2 in ischemic penumbra. PBP@Mg group exhibit a significantly better performance in neurofunctional behavior compared to ischemic group. Taken together, this study provides a novel therapeutic approach for cerebral ischemia\u2010reperfusion injury via anti\u2010oxidative and anti\u2010inflammatory effects.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500929","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T12:36:49Z","timestamp":1744029409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mg\n                    <sup>2+<\/sup>\n                    \u2010Loaded Black Phosphorus Nanosheet Protects against Cerebral Ischemic Injury through Anti\u2010Oxidative and Anti\u2010Inflammatory Effects"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7922-6164","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Jinzhou Medical University Postgraduate Training Base (Zhejiang Provincial People's Hospital)  Hangzhou Zhejiang 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Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Wen","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center Department of Radiology Zhejiang Provincial People's Hospital, Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jinzhou Medical University Postgraduate Training Base (Zhejiang Provincial People's Hospital)  Hangzhou Zhejiang 310014 China"},{"name":"Cancer Center Department of 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