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Effective regeneration remains challenging due to limited material bioactivity and inadequate consideration of mechanical cues. This study develops a hydrogel integrating human extracellular matrix\u2010like collagen (hCol) derived from induced human adipose mesenchymal stem cells (hASCs) with hyaluronic acid (HA) and polyethylene glycol diamine (PEGDA), engineered to achieve a modulus (\u22481\u00a0kPa) representative of subcutaneous soft tissue. The hCol, produced at scale, provides essential biochemical signals, which, in conjunction with the hydrogel mechanical properties, synergistically modulate immune responses, cellular differentiation, and anti\u2010aging processes. Both animal experiments and clinical trials validate the regenerative efficacy of the hydrogels. Clinical regeneration therapy for mandibular retrognathia shows rapid and sustained improvements, with repair efficacy rates of 95.2% at 3 months and 76.2% at 6 months. These findings underscore the hydrogel's ability to reshape the soft tissue microenvironment, supporting immediate tissue repair and sustained regeneration, while offering a promising platform for future biomaterial development in soft tissue engineering.<\/jats:p>","DOI":"10.1002\/adhm.202500953","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:08:46Z","timestamp":1744164526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human Extracellular Matrix\u2010Like Collagen\u2010Based Hydrogels for Soft Tissue Regeneration and Mandibular Retrognathia Treatment"],"prefix":"10.1002","volume":"14","author":[{"given":"E.","family":"Xiao","sequence":"first","affiliation":[{"name":"Xiangya Stomatological Hospital and Xiangya School of Stomatology Academician Workstation for Oral\u2010Maxilofacial and Regenerative Medicine Central South University  Changsha 410008 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