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This study introduces a new approach using natural ferulic acid\u2010based polymer nanoparticles to target CNP. Ferulic acid (FA) is polymerized into poly(ferulic acid) and forms nanoparticles (PFA NPs). Folic acid (Fa) is added for targeting, and celecoxib (Cel) is loaded, creating PFA\u2010Fa@Cel NPs. These nanoparticles, \u2248100\u00a0nm in size, have a 39% drug encapsulation efficiency, showing good stability, biocompatibility, controlled release, and anti\u2010inflammatory effects, including reduced macrophage chemotaxis. PFA NPs demonstrated strong anti\u2010inflammatory effects and targeted oxidative stress reduction while inhibiting pyroptosis. Mechanistic studies showed that PFA\u2010Fa NPs disrupted the KEAP1\/Nrf2 complex, leading to Nrf2 activation, enhanced antioxidant responses, and preservation of prostate epithelium integrity. 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This approach shows significant clinical promise for CNP patients.<\/jats:p>","DOI":"10.1002\/adhm.202500954","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:17:43Z","timestamp":1748315863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inflammation\u2010Targeted and Antioxidative Poly(Ferulic Acid) Nanoparticles Directly Treat Chronic Nonbacterial Prostatitis via Inhibiting Pyroptosis by Disrupting Nrf2\/KEAP1 Multimer Formation and as a Robust Drug Carrier"],"prefix":"10.1002","volume":"14","author":[{"given":"Bingliang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou 510120 China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine Urology Department Sun 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