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Antimicrobial photodynamic therapy (aPDT) typically employs photosensitizers to generate reactive oxygen species (ROS) under irradiation, causing oxidative damage to both bacteria and biofilms. While prior studies have explored the integration of PDT with various other approaches, magnetic hyperthermia therapy (MHT) has not adequately addressed. To bridge this gap, a drug delivery system is designed that incorporates mesoporous Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles loaded with the photosensitizer IR\u2010820, thereby combining aPDT with MHT. This system possesses magnetic\u2010targeting capabilities, generates thermal energy when exposed to alternating magnetic fields, and facilitates the release of encapsulated IR\u2010820. Furthermore, upon exposure to near\u2010infrared light, IR\u2010820 produces ROS. The synergistic effects of elevated temperature, degradation of the biofilm matrix, and enhanced ROS production effectively disrupted bacterial biofilms. This approach demonstrated promising antibacterial efficacy in both in vitro and in vivo, including in rat models of full\u2010thickness infectious wound and subcutaneous abscesses. These results underscore the substantial potential of the system for future antibacterial applications.<\/jats:p>","DOI":"10.1002\/adhm.202500964","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:18:34Z","timestamp":1748315914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mesoporous Fe<sub>3<\/sub>O<sub>4<\/sub> Nanoparticles Loaded with IR\u2010820 for Antibacterial Activity via Magnetic Hyperthermia Combined with Photodynamic Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuange","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 P. R. 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