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Herein, a nitric oxide (NO)\u2010mediated dual\u2010function smart coating with antibacterial and osseointegration\u2010promoting properties is developed for Ti implants. The coating leverages the distinct properties of NO at high and low concentrations to enable an on\u2010demand functional switch. Specifically, antibacterial function is achieved through a rapid release of high\u2010dose NO in response to the infection microenvironment and near\u2010infrared stimulation. Once the infection is resolved and normal physiological conditions are restored, the coating gradually releases low\u2010dose NO to promote osseointegration. In vitro tests confirm that the coating exhibits antibacterial ratio of 97.84% and 97.18% against methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> and its biofilms, respectively, and demonstrates the ability to activate osteoblasts. The rat femoral implant\u2010associated infection model further certifies that the responsive NO release mechanism of the coating efficiently facilitates the on\u2010demand functional switch between antibacterial and osseointegration\u2010promoting properties. Notably, the use of the dual\u2010functional nonantibiotic agent, NO, significantly mitigates the risk of bacterial resistance.<\/jats:p>","DOI":"10.1002\/adhm.202500997","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T06:59:23Z","timestamp":1744095563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Nitric Oxide\u2010Mediated Dual\u2010Functional Smart Titanium Implant Coating for Antibacterial and Osseointegration Promotion in Implant\u2010Associated Infections"],"prefix":"10.1002","volume":"14","author":[{"given":"Zishuo","family":"Hou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LOFE) &amp; Institute of Flexible Electronics (IFE) Shaanxi Key Laboratory of Flexible Electronics &amp; MIIT Key Laboratory of Flexible Electronics (KLoFE) Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) Xi'an Shaanxi 710072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LOFE) &amp; Institute of Flexible Electronics (IFE) Shaanxi Key Laboratory of Flexible Electronics &amp; MIIT Key Laboratory of Flexible Electronics (KLoFE) Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) Xi'an Shaanxi 710072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guming","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LOFE) &amp; Institute of Flexible Electronics (IFE) Shaanxi Key Laboratory of Flexible Electronics &amp; MIIT Key Laboratory of Flexible Electronics (KLoFE) Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) Xi'an Shaanxi 710072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-6336","authenticated-orcid":false,"given":"Zhang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Chongqing Innovation Center Northwestern Polytechnical University  Chongqing 401135 P. R. China"},{"name":"Xi'an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical Research Northwestern Polytechnical University  Xi\u2018an Shaanxi 710072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LOFE) &amp; Institute of Flexible Electronics (IFE) Shaanxi Key Laboratory of Flexible Electronics &amp; MIIT Key Laboratory of Flexible Electronics (KLoFE) Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) Xi'an Shaanxi 710072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi\u2018an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi\u2018an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-9601","authenticated-orcid":false,"given":"Tengjiao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LOFE) &amp; Institute of Flexible Electronics (IFE) Shaanxi Key Laboratory of Flexible Electronics &amp; MIIT Key Laboratory of Flexible Electronics (KLoFE) Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) Xi'an Shaanxi 710072 P. R. China"},{"name":"Chongqing Innovation Center Northwestern Polytechnical University  Chongqing 401135 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-2177","authenticated-orcid":false,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LOFE) &amp; Institute of Flexible Electronics (IFE) Shaanxi Key Laboratory of Flexible Electronics &amp; MIIT Key Laboratory of Flexible Electronics (KLoFE) Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) Xi'an Shaanxi 710072 P. R. 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