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Therefore, the development of novel biomaterials for bone repair is essential. This study employed a hydrothermal method to synthesize hydroxyapatite (HAp) doped with various elements and characterized its physicochemical properties. These findings show that the doped HAp particles have a uniform spherical shape and an even distribution of elements. Subsequently, HAp\u2010GelMA composite hydrogels are synthesized, and their mechanical properties and injectability are assessed. The addition of HAp significantly enhanced the stability of the composite hydrogel, making it suitable for the rapid filling of bone defects. In vitro experiments demonstrated that the Zn\/Mg dual\u2010doped composite hydrogel effectively promoted cell proliferation and angiogenesis. Furthermore, In vivo studies using a cranial defect model in rats show that the Zn\/Mg dual\u2010doped group exhibited significantly better bone regeneration compared to the control group, indicating the material's potential application value in bone tissue engineering and regenerative medicine. In summary, the composite hydrogel scaffold developed in this study shows promising prospects for enhancing angiogenesis and osteogenesis.<\/jats:p>","DOI":"10.1002\/adhm.202501008","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T07:26:07Z","timestamp":1753169167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Novel Injectable Composite Hydrogel HAp\u2010GelMA Co\u2010Doped Magnesium\/Zinc Promotes Bone Generation and Angiogenesis Synergistically"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8411-0650","authenticated-orcid":false,"given":"Lei","family":"Qiang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Children's Hospital of Nanjing Medical University  Nanjing 210008 P. R. 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