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Excessive accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of TP, which compromises tendon repair and integrity through oxidative stress. This process is often accompanied by ferroptosis\u2014a newly recognized form of iron\u2010dependent programmed cell death. This study explores ruthenium oxide (RuO<jats:sub>2<\/jats:sub>) hollow nanospheres as an effective nanozyme to address oxidative damage and ferroptosis in type I collagenase\u2010induced TP. In vitro experiments show decreased mRNA levels of inflammatory biomarkers in tenocytes, while western blot analysis and immunofluorescence reveal reduced extracellular matrix degradation after RuO<jats:sub>2<\/jats:sub> treatment. In the TP model, the RuO<jats:sub>2<\/jats:sub> nanozyme therapy and improves tendon fiber arrangement, alleviates pain, and increases type I collagen expression while preventing matrix degradation. These findings suggest that the RuO<jats:sub>2<\/jats:sub> nanozyme possesses significant antioxidant and anti\u2010inflammatory properties, providing protective effects on tenocytes by ROS scavenging and countering ferroptosis, indicating its potential for treating TP.<\/jats:p>","DOI":"10.1002\/adhm.202501035","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T01:31:58Z","timestamp":1749778318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Chenfeng","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Orthopedics Jinling Clinical Medical College Nanjing University of Chinese Medicine  Nanjing Jiangsu 210002 P. R. 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