{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:54:03Z","timestamp":1788576843855,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52272276"],"award-info":[{"award-number":["52272276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bacterial infections and complex microenvironments induce cellular oxidative stress and cellular senescence severely affect chronic wound healing. However, the antibacterial effect of most dressings is single, which is only against the wound\u2010breeding bacteria but cannot resist further invasion of bacteria in the environment into the wound. Few dressings can simultaneously fulfill antibacterial, antifouling, oxidative stress regulation, and cellular protection. Therefore, a Janus patch (SBMA\/OHA\/GelMA\/TA\u2010CeO<jats:sub>2<\/jats:sub>@HA (HGT\u2010C@HA)) is prepared, in which the top superhydrophilic SBMA zwitterionic layer resists bacterial adhesion, and CeO<jats:sub>2<\/jats:sub> coated with hyaluronic acid (HA) is loaded into the bottom gel as the functional center. After immersion in tannic acid (TA), Ce\u2010TA chelate formation in situ confers photothermal antimicrobial properties to the hydrogel. It is further validated that HA\u2010coated CeO<jats:sub>2<\/jats:sub> enable the dressing to obtain higher antioxidant properties by regulating the proportion of Ce<jats:sup>3+<\/jats:sup> on the nanoparticle surface, which protects cells from the high glucose and high H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> environment and effectively inhibits intracellular DNA damage to mitigate cellular senescence. In vivo experiments illustrate that the material significantly accelerated wound healing and improved the quality of wound healing, demonstrating the significant potential of this dressing in diabetic wound healing.<\/jats:p>","DOI":"10.1002\/adhm.202501042","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:17:00Z","timestamp":1748333820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ceria Centre to Enhance Multi\u2010Active and Photothermal Response Janus Patch for Chronic Wound Senescence Inhibition and Repair"],"prefix":"10.1002","volume":"14","author":[{"given":"Yilin","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC\u2010TRR) South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC\u2010TRR) South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC\u2010TRR) South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC\u2010TRR) South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuzhi","family":"Ma","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC\u2010TRR) South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC\u2010TRR) South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-5799","authenticated-orcid":false,"given":"Xiaodong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC\u2010TRR) South China University of Technology  Guangzhou 510006 China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou 510641 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202213066"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.03.005"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04556"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202402531"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c08883"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404889"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404525"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152511"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202411117"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c01370"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402596"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.8b00850"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760100300041"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn0327"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01502-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c13899"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05409"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.148768"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.03.014"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302858"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4026806"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2024.160256"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cattod.2018.05.059"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00577"},{"key":"e_1_2_8_17_1","volume":"64","author":"Zhang J.","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-022-4666-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.148768"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119940"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315592"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202200177"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b08219"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b13267"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401619"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201905493"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411194"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c00067"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2024.161249"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2024.122542"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14957"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.10.049"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9120767"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.05.017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.12.001"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2023.1292053"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2019.030501"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2023.02.016"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.014"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2023.101638"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131810"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202200949"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c02394"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB00411F"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T14:30:21Z","timestamp":1759761021000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202501042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":56,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/adhm.202501042"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202501042","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"2025-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2501042"}}