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The deployed patches are envisioned to adhere at the tumor site in order to locally deliver high drug amounts to the tissue. The approach is considered as a platform for a gastric patch design that is flexible with reference to size and shape, active pharmaceutical ingredient (API)\u00a0and dosages as well as providing unidirectional drug release. Agarose\u00a0is employed as main component for the patch for its water\u2010actuated shape transformation (curling\u2010shrinkage\/deployment) capabilities. This patch can be compactly deformed upon drying for easy ingestion. The patch is envisioned to rehydrate and expand in the stomach. In order to promote mucoadhesion, agarose\u00a0hydrogel is modified with chitosan\u00a0and included SPIONs to allow for magnetic guidance. The study focuses on the design and fabrication process, physicochemical characterization, and magnetization evaluation of the composite hydrogel. 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By leveraging the combination of 4D printing, magnetic guidance, and localized drug delivery, this patch has the potential to improve the effectiveness of stomach cancer treatments.<\/jats:p>","DOI":"10.1002\/adhm.202501085","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T13:10:39Z","timestamp":1753535439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Deployable 4D Printed, Mucoadhesive and Magnetically Guided Patch for Local Therapy of Gastric Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-4250","authenticated-orcid":false,"given":"Dina B.","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Pharmaceutical Technology Institute of Pharmacy Faculty of Medicine Leipzig University  04317 Leipzig Germany"},{"name":"Department of Pharmaceutics Egyptian Drug Authority, formerly known as National organization for Drug Control and Research Giza Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3229-2514","authenticated-orcid":false,"given":"Martin","family":"B\u00f6rner","sequence":"additional","affiliation":[{"name":"Institute for Inorganic Chemistry Leipzig University  04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-7307","authenticated-orcid":false,"given":"Christian","family":"W\u00f6lk","sequence":"additional","affiliation":[{"name":"Pharmaceutical Technology Institute of Pharmacy Faculty of Medicine Leipzig University  04317 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-1850","authenticated-orcid":false,"given":"Michaela","family":"Schulz\u2010Siegmund","sequence":"additional","affiliation":[{"name":"Pharmaceutical Technology Institute of Pharmacy Faculty of Medicine Leipzig University  04317 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.24353.2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/hygiene3030019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21657"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S502833"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.10.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00973"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112302"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122504"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.06.272"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-023-01414-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2019.04.005"},{"key":"e_1_2_9_13_1","first-page":"1511","author":"d'Argentre\u00b4 A. 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