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Here, a cyclodextrin\u2010based metal\u2010organic framework (CD\u2010MOF) is used as a carrier for 5\u2010ASA (ASA@CM) to enhance its solubility. To improve the targeted release 5\u2010ASA, ASA@CM is incorporated into sodium alginate\/\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arginine complex (SA\u2010LA) to obtain the desired microspheres (ASA@CM\/SL) by electrospray. ASA@CM\/SL safeguards 5\u2010ASA against the harsh gastrointestinal environment and provides favorable delivery to the colon. The anti\u2010inflammatory and anti\u2010oxidant activity is studied by measuring inflammatory factors and reactive oxygen species (ROS). The therapeutic effect of ASA@CM\/SL on UC mice induced with dextran sulfate sodium is assessed. The biosafety by evaluating cytotoxicity and organ toxicity is studied. ASA@CM\/SL shows excellent therapeutic effects for UC, as evidenced by its alleviation of inflammatory response and restoration of disrupted intestinal barriers. ASA@CM\/SL features low cytotoxicity and low organ toxicity. This study provides a potential strategy for improving 5\u2010ASA solubility and delivery efficiency, which may also be applied to broadly tackle various small hydrophobic molecules to treat UC and other intestinal diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501160","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:37:07Z","timestamp":1750649827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CD\u2010MOF Based pH\/ROS Sensitive 5\u2010ASA Delivery System for Ulcerative Colitis Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Yanxue","family":"Si","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral Materials School of Materials Science and Technology China University of Geosciences (Beijing)  Beijing 100083 P. R. 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