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The tightly regulated coupling between osteoblasts and osteoclasts limits the therapeutic efficacy of conventional anti\u2010resorptive agents and anabolic agents. Anti\u2010aging therapy offers a potential strategy to modify the senescent phenotype of bone\u2010associated cells, restore cellular function, and re\u2010establish homeostasis between bone resorption and formation. Calcium\u2010based nanoparticles can effectively deliver therapeutic agents to target sites while simultaneously supplying exogenous calcium. Moreover, restored osteoblast function enhances the cellular capacity to process supplemented exogenous calcium ions, ultimately increasing bone density and further alleviating osteoporosis. In this context, a dual\u2010functional calcium carbonate nanoparticle is engineered. This nanoparticle facilitates the complexation of nicotinamide mononucleotide, enabling targeted delivery to osteoblasts, reversing osteoblast senescence, and restoring their osteogenic function. Simultaneously, through calcium supplementation, the nanoparticle promotes osteoblast differentiation and mineralization. In vitro and in vivo studies have demonstrated the promising therapeutic efficacy of this nanoparticle in treating SOP, providing critical insights for the future development of integrated anti\u2010senescence therapies and calcium supplementation strategies.<\/jats:p>","DOI":"10.1002\/adhm.202501164","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:08:43Z","timestamp":1752570523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dual\u2010Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Caini","family":"Yu","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University  Hangzhou 310058 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