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Surgical suturing has limitations in preventing anastomotic leakage and postoperative adhesion. To address these challenges, a tissue\u2010adhesive, antibacterial, and antioxidant hydrogel is designed to cover and seal colorectal anastomotic wounds. The hydrogel is formed in situ by simply mixing oxidized hyaluronic acid, adipic acid dihydrazide\u2010modified hyaluronic acid, \u03b5\u2010poly\u2010<jats:sc>l<\/jats:sc>\u2010lysine, and tannic acid. The hydrogel exhibits a rapid gelation rate and self\u2010healing ability. Compared with commercial fibrin glue, the hydrogel has superior tissue\u2010adhesive strength and wound sealing performance. The hydrogel displays potent reactive oxygen species scavenging ability and antibacterial activity against both Gram\u2010positive and Gram\u2010negative bacteria. The hydrogel also exhibits good biodegradation and biocompatibility. 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