{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:17:31Z","timestamp":1790072251475,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22193033"],"award-info":[{"award-number":["22193033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22172044"],"award-info":[{"award-number":["22172044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20342"],"award-info":[{"award-number":["U23A20342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current therapeutic strategies for osteoarthritis (OA) predominantly rely on pharmacological interventions; however, the limited bioavailability of these drugs poses a significant challenge. Here, a self\u2010propelled Janus nanomotor is presented for inflammatory\u2010directed target therapy of OA. This system comprises platinum\u2010catalyzed cannabidiol\u2010loaded mesoporous silica nanoparticles encapsulated in chitosan (Pt\u2010CBD\/MSN@CS). Upon injection, the Pt face decomposes the hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) fuel produced from the inflammatory microenvironment. This enables positive chemotactic movement along the concentration gradient of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and effective accumulation at the lesion sites. The targeting efficiency of inflammatory chondrocytes is enhanced by 1.5\u2010fold compared to normal chondrocytes. The low pH in the inflammatory microenvironment triggers the release of CBD, which alleviates oxidative stress, inflammation, and neuropathic pain, and reduces cartilage loss, joint swelling, and osteophyte volume without significant side effects. This nanorobotic delivery strategy offers a promising approach for targeted OA treatment.<\/jats:p>","DOI":"10.1002\/adhm.202501206","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:06:27Z","timestamp":1753171587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inflammatory\u2010Directed Nanomotors for Targeted Osteoarthritis Treatment"],"prefix":"10.1002","volume":"14","author":[{"given":"Leiming","family":"Tao","sequence":"first","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150001 China"},{"name":"Key Laboratory of Science and Engineering for the Multi\u2010modal Prevention and Control of Major Chronic Diseases Ministry of Industry and Institution: Information Technology HIT Zhengzhou Research Institute  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-6865","authenticated-orcid":false,"given":"Qiang","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150001 China"},{"name":"Key Laboratory of Science and Engineering for the Multi\u2010modal Prevention and Control of Major Chronic Diseases Ministry of Industry and Institution: Information Technology HIT Zhengzhou Research Institute  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.11.005"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02632-w"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-01249"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01360-9"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122030"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.adl2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk7251"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202111038"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201903642"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303759"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202417146"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54293-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49217-w"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202003748"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c00162"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2023.09.013"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado6798"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202416684"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305130"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202400082"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11188"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901710"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c04438"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.1063\/5.0029060"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102171"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35709-0"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.abo4160"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149733"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2022.105464"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9010021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2014.06.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.042"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b01277"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202116013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24430"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.01.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001896"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100791"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/NS20200080"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2592"},{"key":"e_1_2_8_22_1","first-page":"1461","volume":"56","author":"H\u00fcgle T.","year":"2016","journal-title":"Rheumatology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2024.2416961"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705920"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101678"},{"key":"e_1_2_8_26_1","volume":"140","author":"Kean T.","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118999"},{"key":"e_1_2_8_26_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2021.08.129"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103729"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c09404"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:06:15Z","timestamp":1761048375000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202501206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":49,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/adhm.202501206"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202501206","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01206"}}