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Herein, a compensatory elevation in calcium\u2010binding protein grancalcin (GCA) levels in monocytes and macrophages of patients and mice with sepsis is observed. <jats:italic>Gca<\/jats:italic> deletion in myeloid cells displays increased inflammation and organ damage in cecal ligation and puncture\u2010induced sepsis. Mechanistically, GCA enhances the phagocytic function of immune cells by regulating intracellular calcium signaling. A GCA@Acrylate\u2010PEG\u2010NHS\/weakly temperature\u2010sensitive gelatin methacrylate (GelMA) microneedle patch (GCA@NHS\/GelMA\u2010MNPs) is designed. In vivo experiments demonstrate that this patch establishes a sustained drug release mechanism, boosts the phagocytic capacity of immune cells, and improves sepsis outcomes by restoring Ca<jats:sup>2+<\/jats:sup> signaling homeostasis. These findings suggest that GCA\u2010loaded hydrogel microneedle patches can be a promising new treatment for sepsis.<\/jats:p>","DOI":"10.1002\/adhm.202501218","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:23:24Z","timestamp":1747117404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Grancalcin Hydrogel Microneedle Patches Alleviate Sepsis via Modulation of Calcium Signaling to Augment Immune Cell Phagocytosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Peng","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Endocrinology Research Center Xiangya Hospital of Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Endocrinology Research Center Xiangya 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