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However, the immunogenicity of ferroptosis and how to controllably activate the self\u2010enhanced antitumor immune response by cellular ferroptosis require further investigation. In this study, a piezoelectric BaTiO<jats:sub>3<\/jats:sub>\u2010based ferroptosis inducer (BTO@Fe) is synthesized for effective cancer immunotherapy. BTO@Fe induces moderate ferroptosis by introducing excess iron and catalyzing the Fenton reaction. When subjected to ultrasound (US) irradiation, the piezoelectrically excited electrons and holes are separated, further catalyzing reactive oxygen species (ROS) generation and glutathione (GSH) consumption and consequently causing intensified ferroptosis and immunogenic cell death (ICD). Moreover, activated CD8<jats:sup>+<\/jats:sup> T cells respond to immune signals by releasing interferon gamma (IFN\u03b3), which sensitizes tumor cells to ferroptosis in an intrinsic mechanism of ferroptosis initiation. The robust ferroptosis originating from exogenous piezocatalytic reactions and the endogenous immune responses demonstrates\u00a0satisfactory in vitro and in vivo antitumor effects. This work suggests that doping\u2010engineered piezoelectric materials with augmented catalytic activity are promising countermeasures for restoring immunogenicity in ferroptotic cells.<\/jats:p>","DOI":"10.1002\/adhm.202501339","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:44:34Z","timestamp":1746175474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Piezoelectric\u2010Triggered Ferroptosis for Cancer Therapy via Cascade\u2010Enhanced Immune Response"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1676-9687","authenticated-orcid":false,"given":"Huijuan","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Eye Health Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. 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