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Conventional scaffolds lack this dual capacity. Here, a biomimetic triple\u2010layer polycaprolactone (PCL)\u2010based scaffold is developed. The cerebral\u2010side electrospun layer incorporates gentamicin sulfate (GS) for antibacterial action, while the cranial\u2010side electrohydrodynamically printed rhombic PCL layer contains nano\u2010hydroxyapatite (nHA) to enhance osteogenesis. A middle GS\/PCL electrospun layer reinforces mechanical strength. The PCL\/GS\/nHA scaffold demonstrates suitable mechanical properties, sustained GS release, and low hemolysis. After seawater immersion or direct\n                    <jats:italic>S. aureus<\/jats:italic>\n                    exposure, it maintains potent antibacterial efficacy and biocompatibility. Additionally, nHA promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro. This multi\u2010functional scaffold combines seawater\u2010resistant antimicrobial performance with osteogenic capacity, offering a promising solution for dura repair in marine environments.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501352","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:17:00Z","timestamp":1748333820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Micro\/Nanofibrous Polycaprolactone Scaffolds Loaded with Gentamicin for Improved Antimicrobial Activities under Seawater Immersion"],"prefix":"10.1002","volume":"14","author":[{"given":"Kaili","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Manufacturing Systems Engineering National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices State Industry\u2010Education Integration Center for 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