{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:02:43Z","timestamp":1791378163975,"version":"4.3.2"},"reference-count":60,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Implant\u2010associated infections remain a significant complication in medicine. often leading to chronic infection, tissue damage, or implant failure. To address this, this work develops a modular, triple\u2010action titanium implant that integrates bacterial repellency, bactericidal activity, and enhanced tissue integration. The implant comprises medical\u2010grade titanium with a co\u2010deposited layer of bacteriophages and collagen stably embedded within a repellent lubricant layer. The collagen layer promotes cell deposition and spreading in vitro. When tested against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , the coating reduces bacterial load by 3.2 logs on the surface and 1.9 logs in the medium, outperforming conventional liquid\u2010infused surfaces. A modified version targeting\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    achieves 4.1\u2010log and 5.2\u2010log reductions, respectively, after a 6\u2010h incubation. When challenging the coating in a sepsis survival model of\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    infection, mice with the phage\u2010activated implants exhibit a 100% survival rate and fully recover from the infection. In comparison, those with pathogen\u2010repellent and untreated titanium implants show survival rates of only 30% and 10%, respectively. Furthermore, phage, but no bacteria, are detected in the bloodstream of mice implanted with phage\u2010activated titanium, suggesting that locally implanted phage\u2010biomaterials can distribute systemically to control blood infections. Therefore, the engineered phage\u2010activated, triple\u2010action biomaterials may prevent implant\u2010associated infections locally and systemically.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501426","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T05:30:55Z","timestamp":1755322255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0013-0975","authenticated-orcid":false,"given":"Martin","family":"Stark","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Bayat","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rahmani","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathura","family":"Thirugnanasampanthar","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4L8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4L8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4L8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wilson","sequence":"additional","affiliation":[{"name":"Halifax Infirmary  1796 Summer St. Halifax NS B3H 3A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Weitz","sequence":"additional","affiliation":[{"name":"Department of Medicine Thrombosis and Atherosclerosis Research Institute and Hamilton Health Sciences McMaster University  Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Hosseinidoust","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"},{"name":"Department of Chemical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4L8 Canada"},{"name":"Farncombe Family Digestive Health Research Institute McMaster University  Hamilton ON L8S 4K1 Canada"},{"name":"Michael DeGroote Institute for Infectious Disease Research McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8757-8002","authenticated-orcid":false,"given":"Tohid F.","family":"Didar","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"},{"name":"Department of Mechanical Engineering McMaster University  1280 Main Street West Hamilton ON L8S 4L8 Canada"},{"name":"Farncombe Family Digestive Health Research Institute McMaster University  Hamilton ON L8S 4K1 Canada"},{"name":"Michael DeGroote Institute for Infectious Disease Research McMaster University  1280 Main Street West Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_9_1_1","volume-title":"Early Revisions of Hip and Knee Replacements in Canada: A Quality, Productivity and Capacity Issue","year":"2020"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.05.050"},{"key":"e_1_2_9_3_1","volume":"14","author":"Kochar S. P.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216556"},{"key":"e_1_2_9_5_1","volume-title":"Focus: A National Look at Sepsis","year":"2009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.06.048"},{"key":"e_1_2_9_7_1","first-page":"280","author":"Kasman L. M.","year":"2022","journal-title":"Brenner's Encyclopedia of Genetics: Second Edition"},{"key":"e_1_2_9_8_1","first-page":"485","volume-title":"Encyclopedia of Microbiology","author":"Green S.","year":"2019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22042-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116586"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04129"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802724"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216640942"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.8b01541"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201905562"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03938"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12149-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00608G"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01062"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01487"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120291"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c19355"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09378-4"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.513242"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TA06625G"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtice.2022.104353"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.12.107"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/la200102z"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10040360"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.09.012"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b13849"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69685-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)87288-7"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA12347G"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.10.036"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.0169"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58040519"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130774"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51496-z"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10091095"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.582779"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12570"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149589"},{"key":"e_1_2_9_45_1","unstructured":"\u201cCCAC \u2013 Canadian Council on Animal Care: Three Rs \u201d can be found underhttps:\/\/ccac.ca\/en\/three\u2010rs\/ n.d."},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23545.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081811"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00012-19"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2013.779370"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03817-12"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01421-13"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11070839"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-022-00806-1"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11050570"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.01135"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-024-01705-x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0634-z"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01783"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201800617"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01943-13"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:16:43Z","timestamp":1766153803000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202501426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":60,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/adhm.202501426"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202501426","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01426"}}