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This study reports a macrophage\u2010loaded hybrid scaffold construction to improve the response efficiency of implant\u2013macrophage\u2013tissue regeneration axis and precisely polarize macrophages toward the pro\u2010regenerative M2 phenotype in vitro, and constructed an M2 macrophage\u2010loaded hybrid scaffold. The feasibility of using a macrophage\u2010loaded hybrid scaffold for immune\u2010mediated periodontal regeneration is studied in vivo and in vitro. The results illustrate that the M2 macrophage\u2010loaded hybrid scaffolds promoted the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro and promoted cell recruitment and angiogenesis in vivo to perform well in early in vivo osteogenesis. 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