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Available antiviral drugs are effective only for specific viruses. It is imperative to develop broad\u2010spectrum antiviral drugs. The heparin sulfate proteoglycan (HSPG) biomimetic strategy holds great promise to design broad\u2010spectrum antiviral materials. However, the reversible binding of HSPG\u2010mimicking nanoparticles with virions presents a potential risk of reinfection. Herein, a sulfonated liposome (SC_Lip) that can trigger phase transition below pH 6.5 is screened to combat viral infection at all stages. SC_Lip can realize pH\u2010induced phase transition, which triggers membrane fusion with viral envelope and subsequent viral inactivation. Therefore, SC_Lip exhibits virucidal activity via membrane fusion with viral envelope in both acidic viral infection microenvironment and intracellular acidic lysosomes. The broad\u2010spectrum virucidal activity of SC_Lip is confirmed by different types of viruses, including coronavirus (SARS\u2010CoV\u20102), retrovirus (LV), and herpesvirus (HSV\u20101). The in vivo antiviral effect of SC_Lip is further verified by a rat HSV\u20101 anterior uveitis model. Overall, SC_Lip with broad\u2010spectrum virucidal ability holds great promise to fight against emerging viral pandemics in the future.<\/jats:p>","DOI":"10.1002\/adhm.202501446","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T11:09:15Z","timestamp":1749467355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Broad\u2010Spectrum Antiviral Phase\u2010Transformable Liposome with Membrane Fusion\u2010Mediated Virucidal Capability"],"prefix":"10.1002","volume":"14","author":[{"given":"Yutong","family":"Li","sequence":"first","affiliation":[{"name":"Eye Center The Second Affiliated Hospital School of Medicine Zhejiang University  Hangzhou 310009 P. R. China"},{"name":"Department of Polymer Science and Engineering MOE Key Laboratory of Macromolecule Synthesis and Functionalization Zhejiang University  Hangzhou 310058 P. R. 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