{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:16:20Z","timestamp":1791288980456,"version":"4.3.0"},"reference-count":36,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030061"],"award-info":[{"award-number":["32030061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52472290"],"award-info":[{"award-number":["52472290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301039"],"award-info":[{"award-number":["32301039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Systemic therapeutic modalities that possess the capability to activate immune response represent efficacious strategy for managing advanced hepatocellular carcinoma (HCC). Nonetheless, the therapeutic efficacy is substantially constrained by the tumor immunosuppressive microenvironment (TIME) engendered by hypoxia and lactate accumulation in the tumor region. Here, an efficient therapeutic strategy based on a biomimetic nanomedicine is established to remodel TIME and stimulate immune activation for HCC treatment. First, Glucose oxidase (GOx)\u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    self\u2010assembled particles (GM) are synthesized by a facile biomineralization process and further loaded with NO donor (L\u2010Arginine, L\u2010Arg) (GMA). Next, the biomimetic nanomedicine is constructed by co\u2010loading GMA and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010lapachone (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010lap, a drug for DNA damage) into nanoliposomes (GMA\u2010LP), which is found to regulate glucose metabolism to reduce lactate production and concurrently generate oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) to alleviate tumor hypoxia, thus mitigating tumor immunosuppression. More importantly,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010Lap released from GMA\u2010LP NPs can induce DNA damage in tumor cells, while NO generated by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010mediated L\u2010Arginine activation further obstructs the self\u2010repair of damaged DNA, thereby ultimately leading to the in situ activation of STING pathway for eliciting antitumor immune response. Overall, this study provides a universally new strategy for an effective treatment toward advanced HCC, presenting great clinical research values and scientific significance.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501457","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T02:38:58Z","timestamp":1751337538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Biomimetic Nanomedicine for Remodeling the Immune Microenvironment to Potentiating Anti\u2010Tumor Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Mingliang","family":"Ning","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. 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