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While hormonal therapies and surgical excision are standard treatments with proven efficacy in alleviating EM symptoms, they are often accompanied by side effects and a high risk of recurrence after surgery. Therefore, there is an urgent need for non\u2010invasive imaging and therapeutic strategies to address this condition effectively. In this study, second\u2010window near\u2010infrared (NIR\u2010II, 1000\u20131700\u00a0nm) fluorescence imaging is employed, which offers superior spatial resolution, deeper tissue penetration, reduced light scattering, and minimal tissue autofluorescence, to identify EM lesions using aggregation\u2010induced emission luminogen dots (AIE dots). The AIE dots exhibited excellent photothermal properties, achieving a photothermal conversion efficiency of 40%. AIE dots efficiently accumulate at the lesion site through the enhanced permeability and retention (EPR) effect and rapidly heat up to 50 \u00b0C under 808\u00a0nm laser irradiation, facilitating the effective ablation of EM lesions. Histological analysis, including hematoxylin and eosin (HE) staining and immunofluorescence staining, confirmed notable reduction of the EM lesions, indicating effective inhibition of lesion progression. This strategy highlights the potential of NIR\u2010II fluorescence\u2010guided photothermal therapy as a promising non\u2010invasive approach for both the diagnosis and treatment of EM.<\/jats:p>","DOI":"10.1002\/adhm.202501464","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:59:57Z","timestamp":1749725997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Highly Stable and Bright NIR\u2010II AIE Dots for Fluorescence Imaging\u2010Guided Photothermal Ablation of Endometriosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhihui","family":"Huang","sequence":"first","affiliation":[{"name":"Center of Obstetrics and Gynecology Peking University Shenzhen Hospital  Shenzhen 518036 P. R. China"},{"name":"Institute of Obstetrics and Gynecology Shenzhen PKU\u2010HKUST Medical Center  Shenzhen 518036 P. R. 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