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This study sought to mitigate this problem by utilizing the patient's blood, serum, or plasma in the transplant. To accomplish this objective, blood additives derived from Sprague\u2013Dawley rats are incorporated within alginate, and human parathyroid cells are encapsulated. The prepared microbeads are monitored for mechanical properties, followed by xenotransplantation into rats for the evaluation of cell function and immunological response. Biodegradation data showed that the structural integrity of the microbeads containing blood and plasma is superior to serum, while the durability of plasma\u2010including microbeads is only comparable to that of the alginate\u2010only group. Plasma\u2010including microbeads released the highest levels of parathyroid hormone (PTH), both in vitro and in vivo. This behavior could be attributed to the beneficial impact of plasma on cellular function while regulating immune response. Blood incorporation provoked an elevated immune response while concurrently offering minimal support to the encapsulated cells. A notable elevation in CCL2 (MCP\u20101) chemokine levels is observed in both blood and alginate\u2010only microbead groups, correlating with CD68 expression. These findings demonstrated that autologous plasma addition may regulate the immune system, thereby diminishing the risk of rejection in cell transplantations.<\/jats:p>","DOI":"10.1002\/adhm.202501483","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:08:12Z","timestamp":1759579692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Alginate Encapsulation: The Role of Autologous Blood Additives in Parathyroid Cell Transplantation"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-6477","authenticated-orcid":false,"given":"\u00d6zge","family":"Karab\u0131y\u0131k Acar","sequence":"first","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering and Natural Sciences Istanbul Okan University Istanbul 34959 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclnihal","family":"Bozda\u011f","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Alperen","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezgi","family":"Hac\u0131hasano\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lal Era","family":"Aydo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u00e7in Delal","family":"Nozhatzadeh","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikrettin","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhan","family":"Aysan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Faculty of Medicine Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-1404","authenticated-orcid":false,"given":"Gamze","family":"Torun K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering Yeditepe University Istanbul 34755 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.07.003"},{"key":"e_1_2_8_2_1","first-page":"289","volume":"105","author":"Sell J.","year":"2022","journal-title":"Am. 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