{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:27:08Z","timestamp":1782516428436,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","award":["HY\u2010202400000003664"],"award-info":[{"award-number":["HY\u2010202400000003664"]}],"id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Urinary tract infections (UTIs) are among the most prevalent bacterial infections and require timely detection to prevent complications such as acute kidney injury and bloodstream infections. Conventional diagnostic methods, such as bacterial culture, are time\u2010consuming and resource\u2010intensive, necessitating more efficient alternatives. To address this, a noncontact colorimetric sensor is developed for rapid UTI prescreening based on volatile organic compounds (VOCs) emitted from Escherichia coli (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ) \u2010 contaminated urine. This system employs a bromocresol green\u2010Nafion composite for the selective detection of\n                    <jats:italic>E. coli<\/jats:italic>\n                    \u2010associated VOCs. Mechanistic studies reveal that\n                    <jats:italic>E. coli<\/jats:italic>\n                    growth increases urinary ammonia concentration, inducing a pH\u2010dependent colorimetric shift in bromocresol green. Nafion enhances specificity by lowering the solution's pH via sulfonic acid (\u2010SO\n                    <jats:sub>3<\/jats:sub>\n                    H) group dissociation, mitigating background ammonia interference while maintaining sensitivity to\n                    <jats:italic>E. coli<\/jats:italic>\n                    \u2010derived VOCs. For practical use, a dual\u2010strip configuration (bromocresol green and bromocresol green + Nafion) is integrated into a chamber accommodating urine\u2010absorbing diapers, enabling real\u2010time, non\u2010contact detection. Experimental results demonstrated that 1.25 wt.% Nafion optimized selectivity, ensuring clear differentiation between normal and\n                    <jats:italic>E. coli<\/jats:italic>\n                    \u2010contaminated urine through colorimetric changes. This sensor provides a simple, rapid, and non\u2010invasive UTI pre\u2010screening tool, especially suitable for infants and individuals with limited access to healthcare.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501532","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:09:58Z","timestamp":1754903398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Non\u2010Contact Colorimetric Sensor Based on Bromocresol Green\u2010Nafion Composite for Rapid Pre\u2010Screening of Urinary Tract Infections"],"prefix":"10.1002","volume":"14","author":[{"given":"Ryun","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Medical and Digital Engineering, College of Engineering Hanyang University  Seoul 04736 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"DRB Research Institute  DRB Industrial Busan 46329 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solpa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical and Digital Engineering, College of Engineering Hanyang University  Seoul 04736 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yoon","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hanyang University College of Medicine  Seoul 04763 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juchan","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Medical and Digital Engineering, College of Engineering Hanyang University  Seoul 04736 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ge","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits Jiangnan University  Wuxi 214122 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits Shandong University  Jinan 250101 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Electronics and Information Engineering Harbin Institute of Technology  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-9009","authenticated-orcid":false,"given":"Yongwoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Medical and Digital Engineering, College of Engineering Hanyang University  Seoul 04736 Republic of Korea"},{"name":"Department of Pharmacology, College of Medicine Hanyang University  Seoul 04736 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199710000-00007"},{"key":"e_1_2_8_2_1","first-page":"1","volume":"26","author":"Niska R.","year":"2010","journal-title":"Natl. Health Stat. Rep."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-022-02506-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289002900909"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.09.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.114889"},{"key":"e_1_2_8_8_1","first-page":"364","volume":"27","author":"Gharbi M.","year":"2019","journal-title":"BMJ"},{"key":"e_1_2_8_9_1","volume":"10","author":"Hsiao C. Y.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7050130"},{"key":"e_1_2_8_11_1","volume-title":"Selected Papers in Molecular Biology by Jacques Monod","author":"Monod J.","year":"2012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.231"},{"key":"e_1_2_8_13_1","volume":"10","author":"Navarro D. F.","year":"2020","journal-title":"BMJ Open"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356177"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-0361.2005.tb00059.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/phn.12543"},{"key":"e_1_2_8_17_1","volume-title":"Handbook of Medical and Health Sciences in Developing Countries: Education, Practice, and Research","author":"Halboup A.","year":"2023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-49489-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202109055"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr090"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70216-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp20X708173"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00328D"},{"key":"e_1_2_8_24_1","unstructured":"National Collaborating Centre for Women\u2019s and Children\u2019s Health Urinary Tract Infection in Children: Diagnosis Treatment and Long\u2010term Management NICE Clinical Guideline (London: RCOG Press 2007) ISBN 9781904752400."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201730"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c05667"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705264"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac1020886"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2016.03.007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cp20645a"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/je000236i"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2015.12.065"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ef700308u"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202401121"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41528-024-00321-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302173"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158979"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116284"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8642628"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.36.3.1577"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06720-5"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:56:36Z","timestamp":1764053796000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202501532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":41,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/adhm.202501532"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202501532","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2025-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01532"}}