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However, the aggregation of photosensitizers in aqueous solutions could hinder their efficacy, leading to reduced generation of reactive oxygen species (ROS) in biological systems and lower therapeutic effectiveness. For the first time, this work discloses a programmed aggregation system based on the nitrobenzoselenadiazole (NBSD) scaffold with varying alkyl chain lengths (C1, C3, and C8), focusing on their potential as photo\u2010activable pyroptosis inducers. This study underscores the significance of molecular design in developing effective photosensitizers and marks a new era in controlling molecular packing and photophysical properties. Among the candidates, NBSD\u2010NOc exhibits superior performances in several areas: (i) aggregation\u2010enhanced PDT effect, (ii) high cellular uptake, (iii) induction of programmed cell death, (iv) implantable properties, and (v) high biocompatibility. Overall, this work highlights the critical balance between aggregation patterns and photophysical properties, presenting a promising strategy for post\u2010surgical management using implantable photosensitizers to address the potential challenge of tumor recurrence.<\/jats:p>","DOI":"10.1002\/adhm.202501567","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T07:05:51Z","timestamp":1754377551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Programmed Aggregation of Lipidated Nitrobenzoselenadiazole as a Photo\u2010Activatable Pyroptosis Inducer"],"prefix":"10.1002","volume":"14","author":[{"given":"Jong Min","family":"An","sequence":"first","affiliation":[{"name":"College of Medicine Kyung Hee University  Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine Graduate School Kyung Hee University Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo In","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute Core Research Institute (CRI) Kyung Hee University  Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do\u2010Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Graduate School Kyung Hee University  Seoul 02447 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine Graduate School 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