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In this study, functional polymer dots (Pdots) are developed to rapidly and precisely image microlesions by extravasating from IBD\u2010associated vasculature and anchoring within the perivascular matrix mediated by collagen. These Pdots are engineered with dual\u2010channel fluorescence (visible\/NIR windows) and photoacoustic (PA) imaging capabilities, making them suitable for non\u2010invasive IBD diagnosis. Diagnosis using these functional Pdots can be completed within 3 h, which is significantly faster than current nanoprobes. Furthermore, the Pdots allow for continuous visualization of the IBD\u2010affected areas for up to 24 h. They are capable of detecting microlesions smaller than 200 \u00b5m, surpassing the resolution achieved in previous studies. Additionally, even when utilizing wide\u2010field stereoscopic fluorescence microscopy, the signal\u2010to\u2010background ratio (SBR) in IBD\u2010affected areas reaches up to 4.75. High\u2010resolution microvascular imaging reveals IBD\u2010associated intestinal vascular remodeling, including mucosal vascular dilation and submucosal pathological angiogenesis at a resolution of 2\u20133 \u00b5m. Notably, IBD induces a marked increase in the proportion of microvessels with diameters less than 20 \u00b5m in the cecum, Peyer's patches (PP), and mesenteric lymph nodes (MLN) of mice. This work establishes functional Pdots as promising nanoplatforms for rapid and precise IBD diagnosis by leveraging the pathological features of IBD\u2010affected areas. Moreover, they facilitate real\u2010time and high\u2010resolution visualization of microvasculature, offering significant potential for guiding therapeutic interventions.<\/jats:p>","DOI":"10.1002\/adhm.202501580","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:39:28Z","timestamp":1753083568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Collagen\u2010Anchoring Polymer Dots Enable Rapid and Precise Detection of Microlesions in Inflammatory Bowel Disease through Perivascular Matrix Accumulation"],"prefix":"10.1002","volume":"14","author":[{"given":"Shuting","family":"Lu","sequence":"first","affiliation":[{"name":"Shanghai Med\u2010X Engineering Center for Medical Equipment and Technology School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200030 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