{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:10:11Z","timestamp":1791583811981,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20121"],"award-info":[{"award-number":["U20A20121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2022J121"],"award-info":[{"award-number":["2022J121"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blood vessels are distributed throughout all tissues\/organs in the human body, serving as a prerequisite for their survival. Vascular stenosis and rupture caused by disease, trauma, or congenital factors often lead to ischemic necrosis of tissues\/organs, which can be life\u2010threatening in severe cases. Engineered biomimetic blood vessels are extensively studied as potential replacements for diseased vessels. However, current research has not yet perfectly integrated vascular structure, spatial distribution, and the arrangement of multi\u2010type cells. Herein, pre\u2010stressed bioprinting is employed to shape a biomimetic vessel, where aligned hydrogel microfibers induced the circumferential arrangement of vascular smooth muscle cells (VSMCs), simulating the muscle alignment of native blood vessels. While, the endothelial layer and adventitia adhered closely to the muscle layer, with endothelial cells specifically expressing CD31 and secreting vascular endothelial growth factor A (VEGFA). More importantly, this biomimetic vessel possesses functions of native blood vessels, particularly in terms of material exchange capability, the ability to withstand physiological blood pressure, and suturability. During the implantation into the abdominal aorta of rabbits, the biomimetic vessel achieves revascularization. In summary, this work provides a novel approach for constructing engineered biomimetic vessels, holding significant promise for the clinical treatment of vascular\u2010related diseases in the future.<\/jats:p>","DOI":"10.1002\/adhm.202501640","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:56:20Z","timestamp":1750067780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Construction of Multilayered Biomimetic Blood Vesselwith BiphasicCellular System Viapre\u2010StressedBioprinting"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-6872","authenticated-orcid":false,"given":"Yang","family":"Luo","sequence":"first","affiliation":[{"name":"Health Science Center Ningbo University  Ningbo 315211 China"},{"name":"The First Affiliated Hospital of Ningbo University  Ningbo 315010 China"},{"name":"Research Institute of Smart Medicine and 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