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To address this, an in situ self\u2010assembled peptide\u2010sonosensitizer conjugate (\n                    <jats:bold>P1<\/jats:bold>\n                    ) is designed for enhancing sonosensitizer cavitation, which achieves specific and highly efficient SDT of tumors. The\n                    <jats:bold>P1<\/jats:bold>\n                    is constructed using a sonosensitizing unit, a gelatinase\u2010responsive unit, a targeting unit, and a sonodynamic enhancing unit. Upon reaching the gelatinase\u2010overexpressed tumor site,\n                    <jats:bold>P1<\/jats:bold>\n                    spontaneously aggregates and forms hollow nanovesicles, enhancing tumor accumulation. Moreover, due to the dense packing of the hydrophobic tails within the hollow nanovesicles, these vesicles undergo substantial deformation when exposed to ultrasound, generating numerous cavitation nuclei. This markedly enhances the cavitation effect, generating more reactive oxygen species (ROS) than dispersed sonosensitizers and enhancing antitumor efficacy. This study presents an in situ self\u2010assembly strategy for nanodrug expansion, enhancing tumor accumulation and sonosensitizer efficacy, thereby providing a new approach for developing safe, efficient, and targeted ultrasound sensitizers.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501655","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:51:01Z","timestamp":1750650661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["In Situ Self\u2010Assembly Enhanced Cavitation for Efficient Sonodynamic Therapy of Tumors"],"prefix":"10.1002","volume":"14","author":[{"given":"Chun\u2010Nan","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Biomedical Engineering Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis &amp; Treatment Key Laboratory of Cognitive Science of State Ethnic Affairs Commission South\u2010Central Minzu University  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST)  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis &amp; Treatment Key Laboratory of Cognitive Science of State Ethnic Affairs Commission South\u2010Central Minzu University  Wuhan 430074 China"},{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST)  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis &amp; Treatment Key Laboratory of Cognitive Science of State Ethnic Affairs Commission South\u2010Central Minzu University  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Bing","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering&amp;Life Science Wuhan University of Technology  No.122 LuoshiRoad Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng\u2010Ying","family":"Qiao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST)  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-0787","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST)  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53488-8"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0MH00613K"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101144"},{"key":"e_1_2_10_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202001107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201906024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42509-7"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202217055"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09760-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphys148"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03777"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007073"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912768"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202113506"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201907954"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00038"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01199-w"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606628"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102601"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/acb7bb"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201814552"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706320"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064535"},{"key":"e_1_2_10_16_2","first-page":"6146","volume":"62","author":"Janssen W. 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