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However, irregular wounds with intricate crevices are prone to hoarding tissue exudate and colonising bacteria. This creates unnecessary headaches for patients and the healthcare system. Herein, a multifunctional immunomodulatory hydrogel for the healing of irregular chronic wounds with bacterial infections is developed. The system, based on the reversible fracture\u2010restructuring property of dynamic chemical bonds, endows the elastic hydrogel with the viscous fluid property. Meanwhile, the bacterial capture properties are utilised to confer the hydrogel with mild and effective antimicrobial properties. By gradually eliminating bacteria and clearing bacteria and bacterial debris from the lesion, the immune stress response is modulated. In addition, the hydrogel adhering to the wound is painlessly removed by dissociation and disruption of the topological cross\u2010linking points. Histopathological analyses revealed that hydrogels alleviate the inflammatory infiltrative condition at the lesion, accelerate the process of angiogenesis and re\u2010epithelialisation, and facilitate the remodelling of the skin and its appendages. Therefore, the multifunctional immunomodulatory hydrogel constructed in this study can efficiently manage the healing of irregular chronic wounds with bacterial infections.<\/jats:p>","DOI":"10.1002\/adhm.202501670","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T06:20:11Z","timestamp":1758694811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multifunctional Immunomodulatory Hydrogel With Bacterial Capture Properties, Intelligently Exhibited Viscous or Elastic Properties and On\u2010Demand Removal Properties for the Treatment of Bacterially Infected Irregular Chronic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiakang","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  130 Meilong Road Shanghai 200237 P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Unit Shaoxing Detachment Zhejiang Provincial Corps of the Chinese People's Armed Police Force (PAP)  Zhejiang 312000 P. R. China"},{"name":"Department of General Practice Residency Training Base The First Affiliated Hospital of Naval Medical University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishuo","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport  Shanghai 200438 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health Shanghai University of Sport  Shanghai 200438 P. R. 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