{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:36:08Z","timestamp":1762202168127,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP243fa827022","JP234fa727001","JP23ama221426"],"award-info":[{"award-number":["JP243fa827022","JP234fa727001","JP23ama221426"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pancreatic ductal adenocarcinoma (PDAC) is an increasing incidence and is the deadliest cancer. Most pancreatic cancer patients present with nonspecific symptoms at an advanced disease stage that is not amenable to curative surgery. Therapies by immune checkpoint inhibitors have proven difficult in the patients with PDAC. It is communicated that cell surface neuraminidase\u20101 (Neu\u20101) is a highly potential target molecule for nanomedicine to improve the therapeutic efficacy and safety of the present first\u2010line therapies in patients with advanced PDAC. Nanosomes composed of an inorganic core and antiadhesive shell of phospholipid monolayer enable active delivery of irinotecan into intracellular space by targeting Neu\u20101. Nanosomal irinotecan is endocytosed efficiently and exhibits synergistically enhanced inhibitory effects on the growth of Panc\u20101 cells in vitro (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 8.07\u00a0n\n                    <jats:sc>m<\/jats:sc>\n                    ) when displayed with an irreversible\u2010mechanism based Neu\u20101 inhibitor that inactivates nucleophiles of Neu\u20101 by a covalent bond formation. Strikingly, in vivo antitumor effects of nanosomal irinotecan revealed that tumor growth in Panc\u20101 xenograft model is inhibited completely by injection at a dose of 5\u00a0mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    six times at 4\u2010day intervals without body weight loss. The preliminary results provide evidence that targeting Neu\u20101 by nanomedicine is a promising drug delivery strategy to a desired chemotherapy in the patients with advanced PDAC.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501673","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:04:47Z","timestamp":1753171487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanosomal Irinotecan Targeting Pancreatic Cancer Cell Surface Neuraminidase\u20101 Sialidase"],"prefix":"10.1002","volume":"14","author":[{"given":"Ken","family":"Murakami","sequence":"first","affiliation":[{"name":"Field of Drug Discovery Research Faculty of Advanced Life Science Graduate School of Life Science Hokkaido University  N21, W11, Kita\u2010ku Sapporo 001\u20130021 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Field of Drug Discovery Research Faculty of Advanced Life Science Graduate School of Life Science Hokkaido University  N21, W11, Kita\u2010ku Sapporo 001\u20130021 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Hirane","sequence":"additional","affiliation":[{"name":"Field of Drug Discovery Research Faculty of Advanced Life Science Graduate School of Life Science Hokkaido University  N21, W11, Kita\u2010ku Sapporo 001\u20130021 Japan"},{"name":"ENU Pharmaceuticals, Inc. Satellite Laboratory Hokkaido University  N21, W11, Kita\u2010ku Sapporo 001\u20130021 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiru","family":"Otaki","sequence":"additional","affiliation":[{"name":"Field of Drug Discovery Research Faculty of Advanced Life Science Graduate School of Life Science Hokkaido University  N21, W11, Kita\u2010ku Sapporo 001\u20130021 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-8418","authenticated-orcid":false,"given":"Shin\u2010Ichiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Field of Drug Discovery Research Faculty of Advanced Life Science Graduate School of Life Science Hokkaido University  N21, W11, Kita\u2010ku Sapporo 001\u20130021 Japan"},{"name":"ENU Pharmaceuticals, Inc. 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