{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:22:58Z","timestamp":1786976578154,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To address the challenges of\u00a0insufficient hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) levels, rapid Fe\n                    <jats:sup>3+<\/jats:sup>\n                    precipitation, and a slow Fenton reaction cycle, tumor\u2010activated, self\u2010accelerating CDT nanocatalysts are synthesized, comprising poly (lactic\u2010co\u2010glycolic acid) (PLGA)\u2010encapsulated Ca\u2010Fe peroxide clusters and polyarginine (R). Nanocatalysts are camouflaged with cancer cell membranes (CCM) to enhance tumor targeting. Additionally, polyarginine tailored the PLGA responsiveness to low H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    levels (50\u2013100\u00a0\u00b5\n                    <jats:sc>m<\/jats:sc>\n                    ). H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    triggered the degradation of PLGA, releasing CaFe clusters to produce Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and additional H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , sustaining the Fenton reaction. Simultaneously, polyarginine releases nitric oxide (NO) in the presence of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , facilitating Fe\n                    <jats:sup>3+<\/jats:sup>\n                    reduction to Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and amplifying \u2022OH generation. In vitro cellular studies demonstrate significantly improved homotypic tumor targeting (6.5\u2010fold increase) and deep spheroid penetration (&gt;120\u00a0\u00b5m), resulting in improved tumor permeability and elevated \u2022OH generation. Additionally, the nanoparticles exhibit dose\u2010dependent cytotoxicity, and polyarginine notably enhanced the cytotoxicity of CCM\u2010PLGA\u2010CaFe NPs, reducing the IC50 value from 216.9 to 43.38\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Apoptosis\/necrosis assay reveals that the elevated \u2022OH generation by CCM\u2010PLGA\u2010CaFe\u2010R NPs preferentially induced necrosis, effectively inhibiting tumor cell proliferation by 76.3% \u00b1 8.4% over a 7\u2010day treatment. Consequently, this TME\u2010responsive, self\u2010accelerating CDT platform demonstrates enhanced therapeutic efficacy through improved tumor targeting, sustained Fenton reaction, and amplified radical generation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501746","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T07:49:23Z","timestamp":1750146563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tumor Microenvironment\u2010responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Jun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Texas A&amp;M University  College Station TX 77843 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering 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