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In this study, a fully integrated flexible sensor based on a PUC\u2010CoNi\u2010LDH@PANI nanocomposite is fabricated. This involves the direct growth of CoNi\u2010double layer hydroxide (CoNi\u2010LDH) through a facile template\u2010free solvothermal treatment, followed by the vapor phase polymerization (VPP) of \u03c0\u2010conjugated polyaniline (PANI) on a flexible electrospun polyurethane\/chitosan (PUC) mat. Electrochemical studies indicate that the PUC\u2010CoNi\u2010LDH@PANI sensor exhibits ultrahigh sensitivity (2\u00a0187.62, 1\u00a0752.06\u00a0\u00b5A m<jats:sc>m<\/jats:sc>\n<jats:sup>\u22121<\/jats:sup> cm<jats:sup>\u22122<\/jats:sup>) across an acceptable linear range (0.001 to 3.70\u00a0m<jats:sc>m<\/jats:sc>) and has an extremely low detection limit (0.13 \u00b5<jats:sc>m<\/jats:sc>). The superior sensing performance is attributed to the synergistic effects of enhanced catalytic activity, dramatically enlarged surface area of CoNi\u2010LDH nano\u2010flake arrays, mass transfer capability, and improved conductivity due to PANI modification. Moreover, this novel, flexible, nanofiber\u2010based sensor demonstrates excellent reliability for practical glucose detection in human sweat, thereby affirming its potential as a candidate for flexible microelectronics and as a top choice for flexible and wearable healthcare diagnostics systems.<\/jats:p>","DOI":"10.1002\/adhm.202501754","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T07:30:32Z","timestamp":1752478232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Durable, Breathable, and Flexible Sensor Based on Vapor\u2010Phase Polymerized PANI\u2010Coated PUC\u2010CoNi\u2010LDH@PANI Composite for Continuous Sweat Glucose Monitoring"],"prefix":"10.1002","volume":"14","author":[{"given":"Devendra","family":"Shrestha","sequence":"first","affiliation":[{"name":"Department of Bionanotechnology and Bioconvergence Engineering Graduate School Jeonbuk National University  Jeonju 561\u2013756 Republic of Korea"},{"name":"Division of Mechanical Design Engineering Jeonbuk National University  Jeonju 561\u2013756 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulsi","family":"Nayaju","sequence":"additional","affiliation":[{"name":"Department of Bionanotechnology and Bioconvergence Engineering Graduate School Jeonbuk National University  Jeonju 561\u2013756 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Won","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Bionanotechnology and Bioconvergence Engineering Graduate School Jeonbuk National University  Jeonju 561\u2013756 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan Babu","family":"Poudel","sequence":"additional","affiliation":[{"name":"Department of Conversion Engineering Jeonbuk National University  Jeonju 561\u2013756 Republic of 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