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To address these limitations, a multifunctional Prussian blue\/Ag\n                    <jats:sub>2<\/jats:sub>\n                    S nanoplatform (PB@Ag\n                    <jats:sub>2<\/jats:sub>\n                    S) is developed, integrating chemodynamic therapy, BBB modulation, and enhanced immunotherapy. Under near\u2010infrared (NIR) irradiation, Fe\n                    <jats:sup>2+<\/jats:sup>\n                    in Prussian blue is oxidized to Fe\n                    <jats:sup>3+<\/jats:sup>\n                    , amplifying chemodynamic therapy through hydroxyl radical generation and glutathione depletion (GSH reduced by 1.9\u2010fold). Concurrently, Fe\n                    <jats:sup>3+<\/jats:sup>\n                    oxidizes thiol groups in Vascular Endothelial cadherin (VE\u2010cadherin), reducing its expression by 40.6% and transiently disrupting the BBB, thereby enhancing intracranial accumulation of the nanoplatform by 3.0\u2010fold. Integrated Ag\n                    <jats:sub>2<\/jats:sub>\n                    S nanoparticles enable real\u2010time treatment monitoring via NIR\u2010II fluorescence imaging. Unlike conventional immunotherapies, which exhibit limited efficacy in glioma due to its immunosuppressive microenvironment, the PB@Ag\n                    <jats:sub>2<\/jats:sub>\n                    S platform uniquely promotes dendritic cell maturation and reprograms tumor\u2010associated macrophages toward the anti\u2010tumor M1 phenotype. This dual immunomodulatory action effectively converts the immunosuppressive \u201ccold\u201d tumor microenvironment into an immunologically active state. In glioma models, this multifunctional platform achieved tumor eradication within 14 days. By integrating photo\u2010controlled multimodal actions, this theranostic platform effectively addresses critical clinical challenges in glioma therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501763","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:48:18Z","timestamp":1758548898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PB@Ag\n                    <sub>2<\/sub>\n                    S Nanoagent with Enhanced Blood\u2013Brain Barrier Penetration and Synergistic Chemodynamic\u2010Immune Therapy via Light\u2010Induced Iron Valence Transition"],"prefix":"10.1002","volume":"15","author":[{"given":"Yangyang","family":"Zhao","sequence":"first","affiliation":[{"name":"Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education) Department of Chemistry Tsinghua University  Beijing 100084 China"},{"name":"State Key Laboratory of Rare 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