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Although antibiotics have exhibited efficient therapeutic efficacy, it is difficult for a single antibiotic to exert synergistic bactericidal effects against both Gram\u2010positive (G\u207a) and Gram\u2010negative (G\n                    <jats:sup>\u2010<\/jats:sup>\n                    ) bacteria in mixed infection. Meanwhile, long\u2010term treatment in high doses is prone to induce drug toxicity and accelerate the emergence of drug\u2010resistance. Therefore, in this study, polymyxin B (PMB, targeting G\n                    <jats:sup>\u2010<\/jats:sup>\n                    bacteria) and bornyl\n                    <jats:italic>p<\/jats:italic>\n                    \u2010aldehyde benzoate (BF, targeting G\u207a bacteria) are introduced to construct pH\u2010responsive carrier\u2010free nanodrug (PBN) via a molecular self\u2010assembly strategy based on dynamic Schiff\u2010base bonding. Once triggered by the acidic microenvironment in infection site, PBN can specifically release PMB and BF synchronously through Schiff\u2010base bond breaking, which then targeting and killing multidrug\u2010resistant\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (MDR\u2010PA) and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MDR\u2010SA), respectively. Compared with PMB\/BF dual\u2010drug administration, PBN presents higher efficiency for disrupting the membrane integrity of mixed infection. Furthermore, in vivo experiments confirm that PBNs can efficiently eliminate bacterial mixed infection to accelerate wound healing. Considering the good biosafety, the carrier\u2010free self\u2010assemble strategy based on different antibiotics provides an innovative route for the treatment of bacterial mixed infections.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501845","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T07:04:49Z","timestamp":1754377489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dual Antibiotics\u2010Based pH\u2010Responsive Carrier\u2010Free Nanodrug against Bacterial Mixed Infection for Accelerated Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Jiali","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 China"},{"name":"Beijing Laboratory of Biomedical Materials Beijing University of 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