{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:37:55Z","timestamp":1792175875836,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870127"],"award-info":[{"award-number":["81870127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20315"],"award-info":[{"award-number":["U22A20315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220126"],"award-info":[{"award-number":["2023A1515220126"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Triple\u2010negative breast cancer (TNBC) poses significant therapeutic challenges due to its aggressive nature and resistance to hormone therapies and human epidermal growth factor receptor 2 (HER2)\u2010targeted treatments. Paclitaxel is a first\u2010line chemotherapy for TNBC. Its nanoformulation, Abraxane (Abx), has gained widespread clinical use. However, the efficacy of Abx is often limited by poor colloidal stability and a lack of active targeting capability. In this study, we aimed to address these limitations through a dual\u2010modification strategy by complexing Abx with spermidine\u2010conjugated dextran (spm\u2010DEX) and coating it with homologous tumor membranes. The resulting nanoformulation, Abx\/spm@4T1, displayed a core\u2010shell structure, enhanced colloidal stability, and preserved the integrity of the membrane proteins. Additionally, Abx\/spm@4T1 leveraged the homotypic targeting ability of membrane proteins and the cationic charge of spm\u2010DEX to enhance cellular uptake and tumor accumulation. In vitro studies demonstrated superior cytotoxicity, induction of apoptosis, and inhibition of migration and invasion in tumor cells. In vivo, Abx\/spm@4T1 exhibited enhanced tumor\u2010targeting efficiency, suppressed primary tumor growth and lung metastasis, while maintaining favorable biosafety with minimal systemic toxicity. This study underscores the potential of combining biomimetic membrane coatings with modifications of cationic spermidine conjugates to overcome the limitations of conventional nanotherapeutics, providing a promising strategy for targeted therapy in TNBC.<\/jats:p>","DOI":"10.1002\/adhm.202501853","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:37:22Z","timestamp":1767598642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arming Abraxane With Cationic Spermidine Conjugate and Homologous Cell Membrane for Enhanced Triple\u2010Negative Breast Cancer Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Yilu","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology General Hospital of Southern Theatre Command of PLA  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"},{"name":"Department of Hematology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyi","family":"Ng","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianren","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology (Guangzhou)  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"},{"name":"Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education) Zhongshan School of Medicine Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"},{"name":"Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology (Guangzhou)  Guangzhou China"},{"name":"Division of Life Science The Hong Kong University of Science and Technology  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hematology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"59","article-title":"Triple\u2010Negative Breast Cancer Advancements in Characterization and Treatment Approach","volume":"28","author":"Hurvitz S.","year":"2016","journal-title":"Current Opinion in Obstetrics & Gynecology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.ejgo4302040"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010020\u201001296\u20105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9120789"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520999201214234421"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.07.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.828810"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029693\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2008.07.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157\u20107439.1000164"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706759"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers1301077"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400410"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.02.023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S295565"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010020\u201000738\u20108"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585\u2010012\u20109471\u20107"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893377"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101526\u20103"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.50.2.57"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.924740"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmay.2025.01.005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.34172\/apb.2020.039"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32270"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.113382aa"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065016"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101248"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2017.0096"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202501853","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:05:45Z","timestamp":1783011945000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202501853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/adhm.202501853"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202501853","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"2025-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01853"}}