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To address this, a novel immunofluorophore (ICGM\u2010B9\u2010FCS), based on a single\u2010domain antibody\u2010dye targeting the CEACAM5 antigen, is coated with trifluoromethyl chitosan (5 mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) for NIR\u2010II bioimaging of colorectal cancer and its distant metastases. ICGM\u2010B9\u2010FCS demonstrates unique advantages over existing intraoperative tumor\u2010guidance bioagents, including resistance to liver metabolism, well\u2010retained bioaffinity (EC\n                    <jats:sub>50<\/jats:sub>\n                    = 58.09 nmol\u00a0L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), enhanced relative quantum yield (up to 12 equivalents), significant redshifts in absorption (from 783 to 957 nm), effective oral delivery to colonic metastases, and in situ exploration of the capillary\u2010lymphatic network transportation. These findings establish a regulatory pathway for modifying immunofluorophores as orally administered bioagents, offering innovative methods for preoperative diagnosis and intraoperative guidance in colorectal cancer.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202501877","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T05:27:21Z","timestamp":1760592441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Administration of Trifluoroacetyl Chitosan\u2013Encapsulated Redshifted Immunofluorophore for NIR\u2010II Bioimaging of Colorectal Metastases"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5348-4747","authenticated-orcid":false,"given":"Yibing","family":"Shi","sequence":"first","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity Shanghai Key Laboratory of Lung Inflammation and Injury Department of 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