{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:15:44Z","timestamp":1791947744373,"version":"4.3.4"},"reference-count":112,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SA 3575\/2\u20131"],"award-info":[{"award-number":["SA 3575\/2\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["497840077"],"award-info":[{"award-number":["497840077"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic wounds often experience delayed healing due to a disrupted microenvironment marked by persistent inflammation and excessive fibrosiswhich leads to tissue dysfunction. Excessive mitochondrial reactive oxygen species (ROS) at the injury siteworsen this by hindering healing and promoting scarring. This study presents a multifunctional microneedle array (MNA) that combines ROS scavenging with accelerated tissue formation. The array contains Flightless I (Flii) siRNA\u2010loaded arginine\u2010functionalized poly (\u03b2\u2010amino ester)\u2010alginate (APA) particles within a hyaluronic acid methacrylate (HaMA) matrix. These siRNA\u2010APA particles enhance ROS scavenging through nitric oxide (NO) delivery and silence Flii expression in HaCaT cells. The synergistic release of NO, arginine, and siRNA reduces pro\u2010inflammatory gene expression (TNF\u2010\u03b1 and IL6), transforming M1 macrophages into the M2 phenotype and aiding the transition from inflammation to proliferation. Studies in a rat chronic wound model demonstrate that applying the siRNA\u2010APA\u2010laden MNA transdermally mitigates scar formation and promotes wound healing by reducing inflammatory responses. This siRNA\u2010APA\u2010laden HaMA MNA, with ROS scavenging and immunomodulatory activity, offers promising insights into effective chronic wound managementand wound dressing applications.<\/jats:p>","DOI":"10.1002\/adhm.202501886","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:58:34Z","timestamp":1755683914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["ROS\u2010Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Mahshid","family":"Kharaziha","sequence":"first","affiliation":[{"name":"Department of Materials Engineering Isfahan University of Technology  Isfahan 84156\u201083111 Iran"},{"name":"Department of Biomaterials Faculty of Engineering Science University of Bayreuth  95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-4195","authenticated-orcid":false,"given":"Sahar","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Faculty of Engineering Science University of Bayreuth  95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Shokri","sequence":"additional","affiliation":[{"name":"Department of Materials Engineering Isfahan University of Technology  Isfahan 84156\u201083111 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohsen","family":"Ahmadi Tafti","sequence":"additional","affiliation":[{"name":"Colorectal Research Center Imam Khomeini hospital complex Tehran University of Medical Sciences  Tehran Iran"},{"name":"Division of Colorectal Surgery Department of Surgery Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Scheibel","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Faculty of Engineering Science University of Bayreuth  95447 Bayreuth Germany"},{"name":"Bayreuther Zentrum f\u00fcr Kolloide und Grenzfl\u00e4chen (BZKG) University of Bayreuth  95447 Bayreuth Germany"},{"name":"Bayreuther Zentrum f\u00fcr Molekulare Biowissenschaften (BZMB) University of Bayreuth  95447 Bayreuth Germany"},{"name":"Bayreuther Materialzentrum (BayMAT) University of Bayreuth  95447 Bayreuth Germany"},{"name":"Bayerisches Polymerinstitut (BPI) University of Bayreuth  95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00377-3"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100176"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404274"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050700"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c01041"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145941"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.01.015"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.6b00325"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM00346A"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110837"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202715"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.01.026"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2024.101792"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.143173"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.07.006"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.04.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2019.0351"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2019.09.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b09417"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC02769A"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09871"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b04921"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00958C"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610682"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666201026152209"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2021.101116"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00847A"},{"key":"e_1_2_8_18_3","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101495"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202400329"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c01703"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5536"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071116"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2143"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/389792"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00981-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00194F"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903637"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NA00290F"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.025"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3112-5_23"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120301"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc3012"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0337-4"},{"key":"e_1_2_8_30_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202113269"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00572G"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.09.161"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.07.005"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36814"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.1217"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115458"},{"key":"e_1_2_8_35_3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200101)54:1<115::AID-JBM14>3.0.CO;2-Q"},{"key":"e_1_2_8_35_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.11.047"},{"key":"e_1_2_8_35_5","doi-asserted-by":"publisher","DOI":"10.1021\/ma035970w"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111350"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB00548D"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00229"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.08.017"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR07708B"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2023.111655"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.11.015"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.11.040"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.023"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900898"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100056"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700182104"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2006.12.010"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121973"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1393-9"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.03.029"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02689-3"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM01179K"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c02675"},{"key":"e_1_2_8_53_1","first-page":"625","volume":"123","author":"Kim Y. W.","year":"2014","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-76997-4"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8AY01339J"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar5308"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03828-4"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-020-03344-7"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.11.021"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101550"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040856"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123414"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.02.002"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153062"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.603508"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142192"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2973"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212488"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203308"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00715-1"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1209"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12398"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2012.0406"},{"key":"e_1_2_8_73_1","first-page":"18","volume":"2","author":"Penn J. W.","year":"2012","journal-title":"Int. J. Burns Trauma"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120641"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14091709"},{"key":"e_1_2_8_76_1","volume-title":"Antioxidant Therapy and its Effectiveness in Oxidative Stress\u2010Mediated Disorders. Oxidative stress in vertebrates and invertebrates: Molecular aspects of cell signaling","author":"Iannitti T.","year":"2011"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-022-00226-6"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.164166"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050678"},{"key":"e_1_2_8_79_1","first-page":"169","volume":"22","author":"Chan H.","year":"2014","journal-title":"J. Aust. Wound Manage. Assoc."},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01495"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140561"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202100874"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020170"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq4539"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2018.045"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.02.029"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213762"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202501886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:59:02Z","timestamp":1781755142000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202501886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":112,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/adhm.202501886"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202501886","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01886"}}