{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:35:39Z","timestamp":1781796939667,"version":"3.54.5"},"reference-count":74,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF21C100001"],"award-info":[{"award-number":["LGF21C100001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22075247"],"award-info":[{"award-number":["22075247"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic pulmonary fibrosis (IPF), a lethal respiratory disease with few treatment options, occurs due to an excessive process of epithelial\u2010mesenchymal transition (EMT) and abnormal accumulation of extracellular matrix (ECM), eventually leading to fibrotic scarring and destruction of alveolar structures. Here, a bioinspired inhalable nanocomplex (CCM\u03c6@PTNPs) is reported for inhibiting the EMT progress and clearing the intrapulmonary ECM, thereby reversing established fibrotic foci in IPF. The nanocomplex consists of a PLGA core loaded with Chinese herbal tetrandrine (TET) and pirfenidone (PFD), and a macrophage cell membrane (M\u03c6) shell modified with collagenase type I (CLN) and collagen\u2010targeting peptide (CBP). Following inhalation, CCM\u03c6@PTNPs achieves precise abilities of targeting and degrading collagen barrier with the aid of CBP and CLN, ultimately achieving efficient penetration and drug delivery of fibrotic lesions in alveoli. The co\u2010delivery of PFD and TET not only inhibited the transforming growth factor\u2010\u03b21(TGF\u2010\u03b21) pathway to achieve collagen modulation but also restored TGF\u2010\u03b21\u2010induced impaired autophagy, which ultimately reduced local collagen production and accelerated clearance, thus synergistically enhancing the lung function of the bleomycin\u2010induced mouse model. In summary, this study proposes a novel inhalation drug delivery strategy for the treatment of IPF.<\/jats:p>","DOI":"10.1002\/adhm.202501916","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:12:49Z","timestamp":1755843169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioinspired Inhalable Nanoparticles Combining Chinese Herbal Tetrandrine with Pirfenidone Overcome Idiopathic Pulmonary Fibrosis via Coordinated Collagen Modulation and Fibroblast Autophagy Regulation"],"prefix":"10.1002","volume":"14","author":[{"given":"Xinrui","family":"Zhang","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Duan","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhi","family":"Xie","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibing","family":"Yu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuteng","family":"Chu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cai","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-9300","authenticated-orcid":false,"given":"Xuanrong","family":"Sun","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"},{"name":"Zhejiang China Resources Sanjiu Zhongyi Pharmaceutical Co., Ltd  Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201403-0566OC"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0801CI"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.831"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202580"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01070-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36314-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114066"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-020-00173-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01950-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1161-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402582"},{"key":"e_1_2_9_12_1","first-page":"999","volume":"59","author":"Dumic I.","year":"2023","journal-title":"Med. Lith."},{"key":"e_1_2_9_13_1","first-page":"6326","volume":"25","author":"Ntolios P.","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.01.009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-12-24"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.02.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.12.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23124"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101679"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022293"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2024.70.2.29"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23155"},{"key":"e_1_2_9_23_1","first-page":"1093","volume":"23","author":"Lai J.\u2010H.","year":"2002","journal-title":"Acta Pharmacol. Sin."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00026"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.11.025"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13339"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.978600"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.027"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.739220"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11090765"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.04.003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1457"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16121584"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000198"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01744-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810509"},{"key":"e_1_2_9_37_1","volume":"14","author":"Shenoy M.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-12-0662"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.01.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.29682"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1444964"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0864-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207020"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12896-024-00869-y"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado4791"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.01.007"},{"key":"e_1_2_9_47_1","first-page":"309","volume":"25","author":"Sun W.","year":"2007","journal-title":"Groundwater"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/immu.1994.1052"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13053342"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.054"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1389823"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.044"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2281156"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_28"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2046448"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810341"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00351"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01569-x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01326-2023"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2899-4"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.008"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.797292"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107798"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108436"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043149"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.04.055"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122218"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03178-2"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106636"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.125130"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.159665"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-024-03720-7"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4966"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00005209"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202501916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:16:05Z","timestamp":1766153765000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202501916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":74,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/adhm.202501916"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202501916","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01916"}}