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This paper presents the preparation of a biomimetic anisotropic aerogel composed of polyvinyl alcohol (PVA), sodium alginate (SA), and MXenes (Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:sub>X<\/jats:sub>\n                    ) via directional freezing. Inspired by plant vascular bundles, the resulting vertically aligned porous structure enhances the mechanical stability of and mass transfer in the material. The aerogel with its high MXene loading and high surface utilization offers remarkable adsorption capacities for urea (221.77\u00a0mg g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and creatinine (138.07\u00a0mg g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). In vitro assays confirm the excellent hemo\u2010 and cytocompatibility of the aerogel. In a rabbit model of acute ischemic kidney injury, two\u2010hour hemoperfusion with the aerogel significantly lowers the urea (38.67 to 16.17\u00a0mmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and creatinine levels (744.62 to 307.46\u00a0\u00b5mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) without observable toxicity. The multidimensional biomimetic multipore anisotropic MXene aerogel presented here is a structurally optimized and biologically safe adsorbent for efficient uremic toxin clearance and a promising alternative to conventional hemodialysis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502056","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T07:02:44Z","timestamp":1758351764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biomimetic Anisotropic Polyvinyl Alcohol\/Sodium Alginate\/MXene Aerogel for Efficient Uremic Toxin Adsorption in Hemoperfusion"],"prefix":"10.1002","volume":"15","author":[{"given":"Liqin","family":"Wu","sequence":"first","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan University National Quality Control Center for Donated Organ Procurement Hubei Key Laboratory of Medical Technology on Transplantation Hubei Provincial Clinical Research Center for Natural Polymer Biological Liver Hubei Engineering Center of Natural Polymer\u2010based Medical Materials  Wuhan 430071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan University National Quality Control Center for Donated Organ Procurement Hubei Key Laboratory of Medical Technology on Transplantation Hubei Provincial Clinical Research Center for Natural Polymer Biological Liver Hubei Engineering Center of Natural Polymer\u2010based Medical Materials  Wuhan 430071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Yue","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan University National Quality Control Center for Donated Organ Procurement Hubei Key Laboratory of Medical Technology on Transplantation Hubei Provincial Clinical Research Center for Natural Polymer Biological Liver Hubei Engineering Center of Natural Polymer\u2010based Medical Materials  Wuhan 430071 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalibinuer","family":"Yasen","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan University National Quality Control Center for Donated Organ Procurement Hubei Key Laboratory of Medical Technology on Transplantation Hubei Provincial Clinical Research Center for Natural Polymer Biological Liver Hubei Engineering Center of Natural Polymer\u2010based Medical Materials  Wuhan 430071 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