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Powerful motivations have been expressed to construct conjugated polymers with near\u2010infrared fluorescence and phototherapeutic behavior. However, it is a dilemma to simultaneously materialize a favorable fluorescence quantum yield (QY) and impressive photothermal conversion efficiency (PCE) as determined by the contradictory photophysical processes. Herein, a typical donor\u2010acceptor structural photothermal agent (PTA) is synthesized, with synergistic elevation of QY and PCE, featuring various donors attached to 2\u2010(2\u2010decyltetradecyl)\u20106,7\u2010dimethyl\u20102\n                    <jats:italic>H<\/jats:italic>\n                    \u2010[1,2,3]triazolo [4,5\u2010\n                    <jats:italic>g<\/jats:italic>\n                    ] quinoxaline acceptor. By virtue of the fluorination strategy to modulate intramolecular D\u2010A interaction and intermolecular stacking states, as well as increasing the recombination energy and non\u2010radiative transitions, as confirmed by solvatochromic effect, the grazing incident wide\u2010angle X\u2010ray diffraction test, and theoretical analyses, the fluorinated polymeric PTA presents superior near\u2010infrared\u2010II (NIR\u2010II) QY of 2.73% and PCE of 67.3%, outperforming its non\u2010fluorinated counterpart. Ultimately, PQTz\u2010fTT is engineered for in vivo NIR\u2010II fluorescence imaging of blood vessels with a high signal\u2010to\u2010noise ratio of 3.14, as well as NIR\u2010II imaging\u2010guided photothermal anti\u2010tumor therapy, enabling 100% tumor ablation on the 4th day with no recurrence over 21days post\u2010treatment. This work further deepens insight into leveraging fluorination strategy to design highly efficient NIR\u2010II fluorophores for cancer diagnosis and therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502069","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T05:29:41Z","timestamp":1755322181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Fluorinated Conjugated Polymer Allows for Enhanced NIR\u2010II Fluorescence Imaging\u2010Guided Photothermal Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Liwen","family":"Hu","sequence":"first","affiliation":[{"name":"School of Optoelectronic Engineering Guangdong Polytechnic Normal University  Guangzhou 510665 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichun","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and School of Pharmaceutical Science Southern Medical University  Guangzhou 510515 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li'e","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and School of Pharmaceutical Science Southern Medical University  Guangzhou 510515 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianze","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology  Guangzhou 510640 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-5096","authenticated-orcid":false,"given":"Ting","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of 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