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Efficacious dressings developed for treating diabetic wounds should address these issues concurrently. Here, a multifunctional hydrogel adhesive system made by photocrosslinking arginine\u2010functionalized methacrylated chitosan with gallic\u2010acid\u2010functionalized gelatin methacryloyl is reported. The resulting scaffold (ACGG) is loaded with a laponite delivery system gorged with Zn\n                    <jats:sup>2+<\/jats:sup>\n                    (Zn@LAP; ZL). Because of the synergy between its components, the complete hydrogel, ACGG\u2010ZL, is robust, flexible, adhesive, biodegradable, and conductive, which is an essential feature for skin wound treatment via electrostimulation (ES). Most importantly, ACGG\u2010ZL released in an intelligent manner two bioactive molecules upon exposure to ROS: antibacterial, antioxidative, and anti\u2010inflammatory NO and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    . In vitro assays indicates that ACGG\u2010ZL eliminates pathogens, including MRSA, and promotes the proliferation of fibroblasts, endothelial cells, and neuronal precursors, which are all involved in skin tissue remodeling. When combined with ES, hemostatic ACGG\u2010ZL accelerated significantly infected skin wound healing in a diabetic animal model by clearing pathogens, quenching inflammation, stimulating fibroblasts, and promoting neurovascular tissue regeneration. Overall, ACGG\u2010ZL with ES provides a multifunctional, efficacious approach for the treatment of complex diabetic injuries.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502097","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T03:53:28Z","timestamp":1750391608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An Antibacterial and Anti\u2010Inflammatory Hemostatic Adhesive with Dual Zn\n                    <sup>2+<\/sup>\n                    and NO Release for the Neurovascular Electrostimulation of Infected Diabetic Wounds"],"prefix":"10.1002","volume":"14","author":[{"given":"Wenlong","family":"Wei","sequence":"first","affiliation":[{"name":"School of Chemistry Chemical Engineering and Life Science Wuhan University of Technology  Wuhan 430070 P. R. 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