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However, current diagnostic tools, including catheter\u2010based systems and ingestible capsules, suffer from poor patient compliance and unreliable pH readings due to sensor degradation in acidic environments. To address this challenge, a robust, composite pH sensor is reported in this work by combining graphene oxide (GO) with covalent organic frameworks (COFs) coatings. Through interfacial polymerization and liquid\u2010phase exfoliation, the COF protective layer is covalently formed on GO sheets, preserving GO integrity in acidic conditions while enhancing electrochemical performance benefitting from the intrinsic porosity of COFs. The COFs nanochannels with sulfonic groups enable selective proton transport, resulting in high ion selectivity and sensitivity (\u224843\u00a0mV\u00a0pH\n                    <jats:sup>\u22121<\/jats:sup>\n                    , in pH 1\u201310). The sensor exhibits excellent linearity, stability, and high reproducibility in simulated gastric fluid. Furthermore, it resists biofouling from mucin\u2010rich environments and maintains performance under cyclic mechanical deformation. The GO\/COFs composites also show biocompatibility with esophageal epithelial cells. These findings suggest that leveraging COFs as biocompatible protective coatings offers a promising strategy for enhancing the robustness and sensitivity of sensing materials in harsh environments and facilitates the future development of ingestible devices for continuous pH monitoring.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502106","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T07:11:35Z","timestamp":1754377895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Robust pH Sensing Using a Graphene Oxide and Covalent Organic Frameworks Composite for Gastro\u2010esophageal Reflux Disease Diagnosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Ahmed H. 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