{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:13:12Z","timestamp":1784945592486,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010638","name":"Huntsman Cancer Institute, University of Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bispecific T\u2010cell engagers show promise in treating multiple myeloma (MM), but challenges remain in adaptability and targeting flexibility. This paper presents a novel T\u2010cell based immunotherapy,\n                    <jats:styled-content>M<\/jats:styled-content>\n                    ulti\u2010\n                    <jats:styled-content>A<\/jats:styled-content>\n                    ntigen\n                    <jats:styled-content>TC<\/jats:styled-content>\n                    ell\n                    <jats:styled-content>H<\/jats:styled-content>\n                    ybridizers (MATCH), a modular, self\u2010assembling T\u2010cell engager designed for versatile and patient\u2010specific cancer targeting. MATCH consists of two components: a B\u2010cell\u2010targeting Fab\u2019 fragment conjugated to a 25\u2010base morpholino oligonucleotide (Fab\u2019\n                    <jats:sub>B cell antigen<\/jats:sub>\n                    \u2010MORF1) and a T\u2010cell engaging anti\u2010CD3 Fab\u2019 fragment conjugated to the complementary morpholino oligonucleotide (Fab\u2019\n                    <jats:sub>CD3<\/jats:sub>\n                    \u2010MORF2). Upon hybridization of MORF1 and MORF2, MATCH enables pre\u2010targeting of malignant cells followed by in situ post\u2010assembly of the bispecific complex, facilitating targeted T\u2010cell recruitment. To enhance antigen specificity based on MM patient expression profile, a panel of Fab\u2019\u2010MORF1 conjugates targeting key MM surface markers (Fab\u2019\n                    <jats:sub>BCMA<\/jats:sub>\n                    \u2010MORF1, Fab\u2019\n                    <jats:sub>SLAMF7<\/jats:sub>\n                    \u2010MORF1, Fab\u2019\n                    <jats:sub>CD38<\/jats:sub>\n                    \u2010MORF1) is developed, which pairs interchangeably with Fab\u2019\n                    <jats:sub>CD3<\/jats:sub>\n                    \u2010MORF2 for T\u2010cell engagement. MATCH effectively induces immune synapse formation and exhibits potent, antigen\u2010specific cytotoxicity across MM cells. Ex vivo validation in patient\u2010derived bone marrow samples confirms significant tumor cell depletion. Preliminary in vivo studies in humanized mouse model demonstrated effective cancer inhibition along with favorable pharmacokinetics and distribution profiles. These findings support MATCH as a flexible and customizable immunotherapy platform with strong translational potential for the treatment of MM.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202502156","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T10:50:26Z","timestamp":1754045426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Self\u2010Assembling Multi\u2010Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma"],"prefix":"10.1002","volume":"14","author":[{"given":"Shannuo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmaceutics University of Utah  Salt Lake City UT 84112 USA"},{"name":"Center for Controlled Chemical Delivery University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmaceutics University of Utah  Salt Lake City UT 84112 USA"},{"name":"Center for Controlled Chemical Delivery University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Al","family":"Faruque","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmaceutics University of Utah  Salt Lake City UT 84112 USA"},{"name":"Center for Controlled Chemical Delivery University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Shami","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Knoechel","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Lohr","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Sborov","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3948-8448","authenticated-orcid":false,"given":"Jiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmaceutics University of Utah  Salt Lake City UT 84112 USA"},{"name":"Center for Controlled Chemical Delivery University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-6944","authenticated-orcid":false,"given":"Jind\u0159ich","family":"Kope\u010dek","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmaceutics University of Utah  Salt Lake City UT 84112 USA"},{"name":"Center for Controlled Chemical Delivery University of Utah  Salt Lake City UT 84112 USA"},{"name":"Department of Biomedical Engineering University of Utah  Salt Lake City UT 84112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203414"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817226"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01338-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0435-7"},{"key":"e_1_2_9_6_1","first-page":"1637","volume":"7","author":"Malaer J. D.","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01003-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117252"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01482-w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.04.048"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4053827"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c06500"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-019-0004-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/oli.1.1997.7.187"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1393-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2025.102825"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(04)75020-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282eee548"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2024.07.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-629527"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06461-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-003-0496-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.133"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.206"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401381"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1403"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25282-3"},{"key":"e_1_2_9_29_1","first-page":"7","volume":"6","author":"Lee J.","year":"2015","journal-title":"Oncology Therapeutics"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000122"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110642"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.CRC-23-0434"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09943-1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-173494"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15073"},{"key":"e_1_2_9_36_1","first-page":"2950","volume":"12","author":"Bal S.","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00493-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.81494"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202502156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:38:21Z","timestamp":1763116701000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202502156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":38,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/adhm.202502156"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202502156","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02156"}}