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It has become clear that the next generation of biomaterials must be multifunctional. Smart biomaterials can respond to environmental or external stimuli, interact in a spatial\u2010temporal manner, and trigger specific tissue\/organism responses. In this study, the fabrication of novel 3D\u2010printed and bioresorbable scaffolds, with embedded crystals that can convert near\u2010infrared (NIR) light into visible light, is presented. It is demonstrated that these biophotonic scaffolds are not only bioactive and bioresorbable, but can also be promising as a platform for the controlled release or activation of photoactivated drugs locally and on demand, under illumination. The scaffolds are analyzed based on their up\u2010conversion spectroscopic properties and their chemical stability in simulated body fluid. Furthermore, it is demonstrated that the up\u2010conversion properties of the scaffolds are sufficient to release the signaling molecule nitric oxide (NO) and to photoisomerize the muscarinic ligand Phthalimide\u2010Azo\u2010Iperoxo (PAI), in a controlled manner, upon NIR light stimulus. Finally, to assess their biocompatibility for potential implantation, a preliminary study is conducted with human adipose stem cells cultured in contact with scaffolds. Live\/dead assays, morphological analysis, CyQUANT analysis, and ion release measurements confirm that, despite some release of the upconverter crystals, the biophotonic materia and its dissolution by\u2010products, are biocompatible. These findings highlight the potential of these bioresorbable biophotonic scaffolds for localized drug release in response to NIR light stimuli.<\/jats:p>","DOI":"10.1002\/adhm.202502163","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T07:05:13Z","timestamp":1755500713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel 3D\u2010Printed Biophotonic Scaffold Displaying Luminescence under Near\u2010Infrared Light for Photopharmacological Activation and Biological Signaling Compound Release"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5866-5054","authenticated-orcid":false,"given":"Sonya","family":"Ghanavati","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Korkeakoulunkatu 3 Tampere 33720 Finland"},{"name":"Photonics Laboratory Tampere University  Korkeakoulunkatu 3 Tampere 33720 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1247-281X","authenticated-orcid":false,"given":"Ekin","family":"Opar","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute for Science and Technology (BIST)  Carrer de Baldiri Reixac 10 Barcelona 08028 Spain"},{"name":"Doctorate Program in Engineering and Applied Science Universitat de Barcelona  Barcelona Spain"},{"name":"Network Biomedical Research Center in Biomaterials, Bioengineering, and Nanomedicine (CIBER\u2010bbn)  Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-4047","authenticated-orcid":false,"given":"Virginia Alessandra","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Korkeakoulunkatu 3 Tampere 33720 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-3859","authenticated-orcid":false,"given":"Carlo","family":"Matera","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute for Science and Technology (BIST)  Carrer de Baldiri Reixac 10 Barcelona 08028 Spain"},{"name":"Department of Pharmaceutical Sciences University of Milan  Via L. Mangiagalli 25 Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-2619","authenticated-orcid":false,"given":"Fabio","family":"Riefolo","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute for Science and Technology (BIST)  Carrer de Baldiri Reixac 10 Barcelona 08028 Spain"},{"name":"Teamit Institute, Partnerships, Barcelona Health Hub  Barcelona 08025 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-3165","authenticated-orcid":false,"given":"Rossella","family":"Castagna","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute for Science and Technology (BIST)  Carrer de Baldiri Reixac 10 Barcelona 08028 Spain"},{"name":"Dipartimento di Chimica Materiali e Ingegneria Chimica \u201cG. Natta\u201d Politecnico di Milano Piazza Leonardo da Vinci 32 Milano 20133 Italy"},{"name":"Department of Biotechnology Latvian Institute of Organic Synthesis  Aizkraukles 21 Riga LV\u20101006 Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2784-4276","authenticated-orcid":false,"given":"Julien","family":"Colombelli","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute for Science and Technology (BIST)  c. 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